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Impact of estrogen use on decline in cognitive function in a representative sample of older community-resident women.

Publication ,  Journal Article
Fillenbaum, GG; Hanlon, JT; Landerman, LR; Schmader, KE
Published in: Am J Epidemiol
January 15, 2001

The authors investigated whether postmenopausal estrogen use helps to maintain cognitive function; a brief screen, the Short Portable Mental Status Questionnaire (SPMSQ), was used. Information was gathered from a stratified, random sample of 1,907 African-American and White women (aged 65-100 years) participating in the longitudinal Duke Established Populations for Epidemiologic Studies of the Elderly project carried out in five urban and rural counties of North Carolina. All women were cognitively unimpaired in 1986-1987 and were evaluated 3 and 6 years later. Decline in cognitive function was measured as an increase of two or more errors on the SPMSQ and crossing of an SPMSQ threshold indicative of cognitive impairment. Recency and continuity of estrogen use were measured. Univariate analyses indicated that recent (crude odds ratio = 0.42, 95% confidence interval: 0.21, 0.86) and continuous (crude odds ratio = 0.32, 95% confidence interval: 0.13, 0.81) estrogen use reduced the risk of cognitive decline but not of cognitive impairment. After adjustment for demographic and health characteristics, protective effects became nonsignificant. While postmenopausal use of estrogen may be protective for Alzheimer's disease, current findings based on a brief cognitive screen suggest that it is not protective for cognitive decline related to aging.

Duke Scholars

Published In

Am J Epidemiol

DOI

ISSN

0002-9262

Publication Date

January 15, 2001

Volume

153

Issue

2

Start / End Page

137 / 144

Location

United States

Related Subject Headings

  • Surveys and Questionnaires
  • Postmenopause
  • Population Surveillance
  • North Carolina
  • Mental Status Schedule
  • Longitudinal Studies
  • Humans
  • Female
  • Estrogen Replacement Therapy
  • Epidemiology
 

Citation

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Chicago
ICMJE
MLA
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Fillenbaum, G. G., Hanlon, J. T., Landerman, L. R., & Schmader, K. E. (2001). Impact of estrogen use on decline in cognitive function in a representative sample of older community-resident women. Am J Epidemiol, 153(2), 137–144. https://doi.org/10.1093/aje/153.2.137
Fillenbaum, G. G., J. T. Hanlon, L. R. Landerman, and K. E. Schmader. “Impact of estrogen use on decline in cognitive function in a representative sample of older community-resident women.Am J Epidemiol 153, no. 2 (January 15, 2001): 137–44. https://doi.org/10.1093/aje/153.2.137.
Fillenbaum GG, Hanlon JT, Landerman LR, Schmader KE. Impact of estrogen use on decline in cognitive function in a representative sample of older community-resident women. Am J Epidemiol. 2001 Jan 15;153(2):137–44.
Fillenbaum, G. G., et al. “Impact of estrogen use on decline in cognitive function in a representative sample of older community-resident women.Am J Epidemiol, vol. 153, no. 2, Jan. 2001, pp. 137–44. Pubmed, doi:10.1093/aje/153.2.137.
Fillenbaum GG, Hanlon JT, Landerman LR, Schmader KE. Impact of estrogen use on decline in cognitive function in a representative sample of older community-resident women. Am J Epidemiol. 2001 Jan 15;153(2):137–144.
Journal cover image

Published In

Am J Epidemiol

DOI

ISSN

0002-9262

Publication Date

January 15, 2001

Volume

153

Issue

2

Start / End Page

137 / 144

Location

United States

Related Subject Headings

  • Surveys and Questionnaires
  • Postmenopause
  • Population Surveillance
  • North Carolina
  • Mental Status Schedule
  • Longitudinal Studies
  • Humans
  • Female
  • Estrogen Replacement Therapy
  • Epidemiology