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Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse.

Publication ,  Journal Article
Chen, BJ; Deoliveira, D; Cui, X; Le, NT; Son, J; Whitesides, JF; Chao, NJ
Published in: Blood
April 1, 2007

Several groups, including our own, have independently demonstrated that effector memory T cells from non-alloantigen-primed donors do not cause graft-versus-host disease (GVHD). In the current study, we further investigated whether this approach could be extended to all memory T cells, and we studied the underlying mechanisms. Neither total memory T cells nor purified central memory T cells were able to induce GVHD. Memory T cells were at least 3-log less potent than bulk T cells in mediating GVHD. As expected, memory T cells failed to elicit cytotoxicity and proliferated poorly against alloantigens in standard 5-day mixed-lymphocyte cultures. However, the proliferative responses of memory T cells were more comparable with those of bulk and naive T cells when the culture time was shortened. Moreover, the frequencies of IL-2-secreting cells measured by 42-hour enzyme-linked immunosorbent spot (ELISPOT) assay were similar among naive, memory, and bulk T cells. These data indicated that memory T cells are able to respond to alloantigens initially but fail to develop to full potential. The abortive immune response, which was mediated by non-alloantigen-specific memory T cells in response to alloantigens, may explain why memory T cells from unprimed and non-alloantigen-primed donors could not induce GVHD.

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Published In

Blood

DOI

ISSN

0006-4971

Publication Date

April 1, 2007

Volume

109

Issue

7

Start / End Page

3115 / 3123

Location

United States

Related Subject Headings

  • T-Lymphocyte Subsets
  • Stem Cell Transplantation
  • Mice, Inbred C57BL
  • Mice, Inbred C3H
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Lymphocyte Culture Test, Mixed
  • Isoantigens
  • In Vitro Techniques
 

Citation

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Chen, B. J., Deoliveira, D., Cui, X., Le, N. T., Son, J., Whitesides, J. F., & Chao, N. J. (2007). Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse. Blood, 109(7), 3115–3123. https://doi.org/10.1182/blood-2006-04-016410
Chen, Benny J., Divino Deoliveira, Xiuyu Cui, Ngocdiep T. Le, Jessica Son, John F. Whitesides, and Nelson J. Chao. “Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse.Blood 109, no. 7 (April 1, 2007): 3115–23. https://doi.org/10.1182/blood-2006-04-016410.
Chen BJ, Deoliveira D, Cui X, Le NT, Son J, Whitesides JF, et al. Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse. Blood. 2007 Apr 1;109(7):3115–23.
Chen, Benny J., et al. “Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse.Blood, vol. 109, no. 7, Apr. 2007, pp. 3115–23. Pubmed, doi:10.1182/blood-2006-04-016410.
Chen BJ, Deoliveira D, Cui X, Le NT, Son J, Whitesides JF, Chao NJ. Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse. Blood. 2007 Apr 1;109(7):3115–3123.

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

April 1, 2007

Volume

109

Issue

7

Start / End Page

3115 / 3123

Location

United States

Related Subject Headings

  • T-Lymphocyte Subsets
  • Stem Cell Transplantation
  • Mice, Inbred C57BL
  • Mice, Inbred C3H
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Lymphocyte Culture Test, Mixed
  • Isoantigens
  • In Vitro Techniques