Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions.
Publication
, Journal Article
Maragos, WF; Tillman, PA; Chesnut, MD; Jakel, RJ
Published in: Brain Res
July 10, 1999
We have previously shown that dopamine depletion reduces striatal damage elicited by the mitochondrial neurotoxins malonate and 3-nitropropionic acid (3NP). Metabolism of dopamine by monoamine oxidase results in the formation of hydrogen peroxide, which may mediate dopamine toxicity. In this study, administration of the monoamine oxidase inhibitors clorgyline and deprenyl resulted in a 42% and 75% reduction in lesion volumes in malonate- and 3NP-treated animals, respectively, compared to controls.
Duke Scholars
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
July 10, 1999
Volume
834
Issue
1-2
Start / End Page
168 / 172
Location
Netherlands
Related Subject Headings
- Succinate Dehydrogenase
- Selegiline
- Reference Values
- Rats, Sprague-Dawley
- Rats
- Propionates
- Oxidoreductases
- Nitro Compounds
- Neurotoxins
- Neurology & Neurosurgery
Citation
APA
Chicago
ICMJE
MLA
NLM
Maragos, W. F., Tillman, P. A., Chesnut, M. D., & Jakel, R. J. (1999). Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions. Brain Res, 834(1–2), 168–172. https://doi.org/10.1016/s0006-8993(99)01487-0
Maragos, W. F., P. A. Tillman, M. D. Chesnut, and R. J. Jakel. “Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions.” Brain Res 834, no. 1–2 (July 10, 1999): 168–72. https://doi.org/10.1016/s0006-8993(99)01487-0.
Maragos WF, Tillman PA, Chesnut MD, Jakel RJ. Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions. Brain Res. 1999 Jul 10;834(1–2):168–72.
Maragos, W. F., et al. “Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions.” Brain Res, vol. 834, no. 1–2, July 1999, pp. 168–72. Pubmed, doi:10.1016/s0006-8993(99)01487-0.
Maragos WF, Tillman PA, Chesnut MD, Jakel RJ. Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions. Brain Res. 1999 Jul 10;834(1–2):168–172.
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
July 10, 1999
Volume
834
Issue
1-2
Start / End Page
168 / 172
Location
Netherlands
Related Subject Headings
- Succinate Dehydrogenase
- Selegiline
- Reference Values
- Rats, Sprague-Dawley
- Rats
- Propionates
- Oxidoreductases
- Nitro Compounds
- Neurotoxins
- Neurology & Neurosurgery