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Urinary biomarkers of oxidative status.

Publication ,  Journal Article
Il'yasova, D; Scarbrough, P; Spasojevic, I
Published in: Clin Chim Acta
October 9, 2012

Oxidative damage produced by reactive oxygen species (ROS) has been implicated in the etiology and pathology of many health conditions, including a large number of chronic diseases. Urinary biomarkers of oxidative status present a great opportunity to study redox balance in human populations. With urinary biomarkers, specimen collection is non-invasive and the organic/metal content is low, which minimizes the artifactual formation of oxidative damage to molecules in specimens. Also, urinary levels of the biomarkers present intergraded indices of redox balance over a longer period of time compared to blood levels. This review summarizes the criteria for evaluation of biomarkers applicable to epidemiological studies and evaluation of several classes of biomarkers that are formed non-enzymatically: oxidative damage to lipids, proteins, DNA, and allantoin, an oxidative product of uric acid. The review considers formation, metabolism, and exertion of each biomarker, available data on validation in animal and clinical models of oxidative stress, analytical approaches, and their intra- and inter-individual variation. The recommended biomarkers for monitoring oxidative status over time are F₂-isoprostanes and 8-oxodG. For inter-individual comparisons, F₂-isoprostanes are recommended, whereas urinary 8-oxodG levels may be confounded by differences in the DNA repair capacity. Promising urinary biomarkers include allantoin, acrolein-lysine, and dityrosine.

Duke Scholars

Published In

Clin Chim Acta

DOI

EISSN

1873-3492

Publication Date

October 9, 2012

Volume

413

Issue

19-20

Start / End Page

1446 / 1453

Location

Netherlands

Related Subject Headings

  • Uric Acid
  • Tyrosine
  • Reactive Oxygen Species
  • Oxidative Stress
  • Oxidation-Reduction
  • Lipid Peroxidation
  • Humans
  • Glycation End Products, Advanced
  • General Clinical Medicine
  • F2-Isoprostanes
 

Citation

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Il’yasova, D., Scarbrough, P., & Spasojevic, I. (2012). Urinary biomarkers of oxidative status. Clin Chim Acta, 413(19–20), 1446–1453. https://doi.org/10.1016/j.cca.2012.06.012
Il’yasova, Dora, Peter Scarbrough, and Ivan Spasojevic. “Urinary biomarkers of oxidative status.Clin Chim Acta 413, no. 19–20 (October 9, 2012): 1446–53. https://doi.org/10.1016/j.cca.2012.06.012.
Il’yasova D, Scarbrough P, Spasojevic I. Urinary biomarkers of oxidative status. Clin Chim Acta. 2012 Oct 9;413(19–20):1446–53.
Il’yasova, Dora, et al. “Urinary biomarkers of oxidative status.Clin Chim Acta, vol. 413, no. 19–20, Oct. 2012, pp. 1446–53. Pubmed, doi:10.1016/j.cca.2012.06.012.
Il’yasova D, Scarbrough P, Spasojevic I. Urinary biomarkers of oxidative status. Clin Chim Acta. 2012 Oct 9;413(19–20):1446–1453.
Journal cover image

Published In

Clin Chim Acta

DOI

EISSN

1873-3492

Publication Date

October 9, 2012

Volume

413

Issue

19-20

Start / End Page

1446 / 1453

Location

Netherlands

Related Subject Headings

  • Uric Acid
  • Tyrosine
  • Reactive Oxygen Species
  • Oxidative Stress
  • Oxidation-Reduction
  • Lipid Peroxidation
  • Humans
  • Glycation End Products, Advanced
  • General Clinical Medicine
  • F2-Isoprostanes