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Effects of pregabalin on heart rate variability in patients with painful diabetic neuropathy.

Publication ,  Journal Article
Jiang, W; Ladd, S; Martsberger, C; Feinglos, M; Spratt, SE; Kuchibhatla, M; Green, J; Krishnan, R
Published in: J Clin Psychopharmacol
April 2011

UNLABELLED: Many studies have demonstrated that low heart rate variability (HRV) is a risk for high mortality and morbidity in patients with cardiovascular diseases. The primary purpose of the study was to evaluate whether pregabalin improves HRV in patients with diabetes and painful peripheral neuropathy. Resting heart rates were collected by using the LifeShirt System, developed by VivoMetrics (Ventura, Calif), at baseline and at the end of a 4-week intervention of pregabalin or placebo in patients with painful diabetic peripheral neuropathy. Heart rate variability analysis was performed on the collected R-R intervals using the Vivo- VMLA-036-00 3 Logic of the LifeShirt system. Of the 40 patients enrolled in the study, 70% completed the end of 4-week assessments (n = 15 in pregabalin and n = 14 in placebo). Compared with placebo, pregabalin treatment resulted in significant improvement in HRV measured by frequency domain analysis, that is, a reduction in low frequency-high frequency ratio (-1.30 ± 2.89 vs 0.37 ± 0.33, P = 0.03) and power of normalized low frequency (-0.049 ± 0.092 vs 0.0066 ± 0.023, P = 0.02), as well as an increase in power of normalized high frequency (0.039 ± 0.094 vs -0.038 ± 0.066, P = 0.02). Furthermore, pregabalin resulted in greater reduction of pain and symptoms of anxiety and greater improvement of quality of life. The improvement of HRV measures were not correlated with change of those measures. In conclusion, 4-week pregabalin treatment improved HRV in patients with painful diabetic peripheral neuropathy. TRIAL REGISTRATION: NCT00573261 (clinicaltrials.gov).

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Published In

J Clin Psychopharmacol

DOI

EISSN

1533-712X

Publication Date

April 2011

Volume

31

Issue

2

Start / End Page

207 / 213

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Treatment Outcome
  • Psychiatry
  • Pregabalin
  • Pain Measurement
  • Middle Aged
  • Male
  • Humans
  • Heart Rate
  • Female
 

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Jiang, W., Ladd, S., Martsberger, C., Feinglos, M., Spratt, S. E., Kuchibhatla, M., … Krishnan, R. (2011). Effects of pregabalin on heart rate variability in patients with painful diabetic neuropathy. J Clin Psychopharmacol, 31(2), 207–213. https://doi.org/10.1097/JCP.0b013e31820f4f57
Jiang, Wei, Shelby Ladd, Carolyn Martsberger, Mark Feinglos, Susan E. Spratt, Maragatha Kuchibhatla, Jennifer Green, and Ranga Krishnan. “Effects of pregabalin on heart rate variability in patients with painful diabetic neuropathy.J Clin Psychopharmacol 31, no. 2 (April 2011): 207–13. https://doi.org/10.1097/JCP.0b013e31820f4f57.
Jiang W, Ladd S, Martsberger C, Feinglos M, Spratt SE, Kuchibhatla M, et al. Effects of pregabalin on heart rate variability in patients with painful diabetic neuropathy. J Clin Psychopharmacol. 2011 Apr;31(2):207–13.
Jiang, Wei, et al. “Effects of pregabalin on heart rate variability in patients with painful diabetic neuropathy.J Clin Psychopharmacol, vol. 31, no. 2, Apr. 2011, pp. 207–13. Pubmed, doi:10.1097/JCP.0b013e31820f4f57.
Jiang W, Ladd S, Martsberger C, Feinglos M, Spratt SE, Kuchibhatla M, Green J, Krishnan R. Effects of pregabalin on heart rate variability in patients with painful diabetic neuropathy. J Clin Psychopharmacol. 2011 Apr;31(2):207–213.

Published In

J Clin Psychopharmacol

DOI

EISSN

1533-712X

Publication Date

April 2011

Volume

31

Issue

2

Start / End Page

207 / 213

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Treatment Outcome
  • Psychiatry
  • Pregabalin
  • Pain Measurement
  • Middle Aged
  • Male
  • Humans
  • Heart Rate
  • Female