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External beam radiation therapy for clinically localized prostate cancer: when and how we optimize with concurrent hormonal deprivation.

Publication ,  Journal Article
Koontz, BF; Lee, WR
Published in: Arch Esp Urol
October 2011

Androgen deprivation plays a major role in the treatment of prostate cancer.Preclinical studies have shown that androgen deprivation provides both an independent cytotoxic effect and radiosensitization on prostate tumors. For men with non-metastatic prostate cancer, the addition of androgen deprivation to radiotherapy has been shown to improve survival for intermediate and high risk disease compared to radiation alone.This review discusses the clinical trial data regarding combination of androgen deprivation and radiation and provides recommendations for its use in men undergoing radiotherapy for localized prostate cancer.

Duke Scholars

Published In

Arch Esp Urol

EISSN

1576-8260

Publication Date

October 2011

Volume

64

Issue

8

Start / End Page

858 / 864

Location

Spain

Related Subject Headings

  • Urology & Nephrology
  • Treatment Outcome
  • Risk
  • Randomized Controlled Trials as Topic
  • Radiotherapy, High-Energy
  • Prostatic Neoplasms
  • Neoplasms, Hormone-Dependent
  • Neoadjuvant Therapy
  • Multicenter Studies as Topic
  • Male
 

Published In

Arch Esp Urol

EISSN

1576-8260

Publication Date

October 2011

Volume

64

Issue

8

Start / End Page

858 / 864

Location

Spain

Related Subject Headings

  • Urology & Nephrology
  • Treatment Outcome
  • Risk
  • Randomized Controlled Trials as Topic
  • Radiotherapy, High-Energy
  • Prostatic Neoplasms
  • Neoplasms, Hormone-Dependent
  • Neoadjuvant Therapy
  • Multicenter Studies as Topic
  • Male