A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies.
Publication
, Journal Article
Doria-Rose, NA; Georgiev, I; O'Dell, S; Chuang, G-Y; Staupe, RP; McLellan, JS; Gorman, J; Pancera, M; Bonsignori, M; Haynes, BF; Burton, DR ...
Published in: J Virol
August 2012
Antibody PG9 is a prototypical member of a class of V1/V2-directed antibodies that effectively neutralizes diverse strains of HIV-1. We analyzed strain-specific resistance to PG9 using sequence and structural information. For multiply resistant strains, mutations in a short segment of V1/V2 resulted in gain of sensitivity to PG9 and related V1/V2 neutralizing antibodies, suggesting both a common mechanism of HIV-1 resistance to and a common mode of recognition by this class of antibodies.
Duke Scholars
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Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
August 2012
Volume
86
Issue
15
Start / End Page
8319 / 8323
Location
United States
Related Subject Headings
- Virology
- Structure-Activity Relationship
- Humans
- HIV-1
- HIV Envelope Protein gp120
- HIV Antibodies
- Antibodies, Neutralizing
- Amino Acid Sequence
- 32 Biomedical and clinical sciences
- 31 Biological sciences
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MLA
NLM
Doria-Rose, N. A., Georgiev, I., O’Dell, S., Chuang, G.-Y., Staupe, R. P., McLellan, J. S., … Mascola, J. R. (2012). A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies. J Virol, 86(15), 8319–8323. https://doi.org/10.1128/JVI.00696-12
Doria-Rose, Nicole A., Ivelin Georgiev, Sijy O’Dell, Gwo-Yu Chuang, Ryan P. Staupe, Jason S. McLellan, Jason Gorman, et al. “A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies.” J Virol 86, no. 15 (August 2012): 8319–23. https://doi.org/10.1128/JVI.00696-12.
Doria-Rose NA, Georgiev I, O’Dell S, Chuang G-Y, Staupe RP, McLellan JS, et al. A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies. J Virol. 2012 Aug;86(15):8319–23.
Doria-Rose, Nicole A., et al. “A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies.” J Virol, vol. 86, no. 15, Aug. 2012, pp. 8319–23. Pubmed, doi:10.1128/JVI.00696-12.
Doria-Rose NA, Georgiev I, O’Dell S, Chuang G-Y, Staupe RP, McLellan JS, Gorman J, Pancera M, Bonsignori M, Haynes BF, Burton DR, Koff WC, Kwong PD, Mascola JR. A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies. J Virol. 2012 Aug;86(15):8319–8323.
Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
August 2012
Volume
86
Issue
15
Start / End Page
8319 / 8323
Location
United States
Related Subject Headings
- Virology
- Structure-Activity Relationship
- Humans
- HIV-1
- HIV Envelope Protein gp120
- HIV Antibodies
- Antibodies, Neutralizing
- Amino Acid Sequence
- 32 Biomedical and clinical sciences
- 31 Biological sciences