Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration.
Publication
, Journal Article
Alessenko, A; Khan, WA; Wetsel, WC; Hannun, YA
Published in: Biochem Biophys Res Commun
February 14, 1992
Using isoenzyme-specific antisera, protein kinase C (PKC) alpha and PKC delta were detected in total liver homogenate and in isolated nuclei. PKC beta I, beta II, epsilon, epsilon', and zeta were not detected. During liver regeneration, nuclear PKC alpha levels decreased while PKC delta levels increased. These studies demonstrate, for the first time, the presence of a calcium-independent PKC isoenzyme in liver nuclei and suggest that PKC alpha and PKC delta may have different roles in liver regeneration and cell proliferation.
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Published In
Biochem Biophys Res Commun
DOI
ISSN
0006-291X
Publication Date
February 14, 1992
Volume
182
Issue
3
Start / End Page
1333 / 1339
Location
United States
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Protein Kinase C
- Nuclear Envelope
- Male
- Liver Regeneration
- Liver
- Isoenzymes
- Electrophoresis, Polyacrylamide Gel
- Cell Nucleus
Citation
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MLA
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Alessenko, A., Khan, W. A., Wetsel, W. C., & Hannun, Y. A. (1992). Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration. Biochem Biophys Res Commun, 182(3), 1333–1339. https://doi.org/10.1016/0006-291x(92)91879-u
Alessenko, A., W. A. Khan, W. C. Wetsel, and Y. A. Hannun. “Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration.” Biochem Biophys Res Commun 182, no. 3 (February 14, 1992): 1333–39. https://doi.org/10.1016/0006-291x(92)91879-u.
Alessenko A, Khan WA, Wetsel WC, Hannun YA. Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration. Biochem Biophys Res Commun. 1992 Feb 14;182(3):1333–9.
Alessenko, A., et al. “Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration.” Biochem Biophys Res Commun, vol. 182, no. 3, Feb. 1992, pp. 1333–39. Pubmed, doi:10.1016/0006-291x(92)91879-u.
Alessenko A, Khan WA, Wetsel WC, Hannun YA. Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration. Biochem Biophys Res Commun. 1992 Feb 14;182(3):1333–1339.
Published In
Biochem Biophys Res Commun
DOI
ISSN
0006-291X
Publication Date
February 14, 1992
Volume
182
Issue
3
Start / End Page
1333 / 1339
Location
United States
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Protein Kinase C
- Nuclear Envelope
- Male
- Liver Regeneration
- Liver
- Isoenzymes
- Electrophoresis, Polyacrylamide Gel
- Cell Nucleus