Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts.
Publication
, Journal Article
Bergamaschi, S; Binetti, G; Govoni, S; Wetsel, WC; Battaini, F; Trabucchi, M; Bianchetti, A; Racchi, M
Published in: Neurosci Lett
December 1, 1995
The present study shows that cultured fibroblasts from sporadic Alzheimer's disease patients are deficient in protein kinase C-regulated secretion of amyloid precursor protein. In particular, Alzheimer fibroblasts show a reduced basal secretion and a reduced response at low concentrations of phorbol-12,13-dibutyrate, with an EC50 twofold higher than control fibroblasts. Furthermore, we observed that such defective regulation of the amyloid precursor secretion can possibly be correlated to a specific defect in protein kinase C alpha in fibroblasts from Alzheimer patients.
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Published In
Neurosci Lett
DOI
ISSN
0304-3940
Publication Date
December 1, 1995
Volume
201
Issue
1
Start / End Page
1 / 5
Location
Ireland
Related Subject Headings
- Stimulation, Chemical
- Skin
- Protein Kinase C
- Phorbol 12,13-Dibutyrate
- Middle Aged
- Male
- Isoenzymes
- Humans
- Fibroblasts
- Female
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Bergamaschi, S., Binetti, G., Govoni, S., Wetsel, W. C., Battaini, F., Trabucchi, M., … Racchi, M. (1995). Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts. Neurosci Lett, 201(1), 1–5. https://doi.org/10.1016/0304-3940(95)12168-4
Bergamaschi, S., G. Binetti, S. Govoni, W. C. Wetsel, F. Battaini, M. Trabucchi, A. Bianchetti, and M. Racchi. “Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts.” Neurosci Lett 201, no. 1 (December 1, 1995): 1–5. https://doi.org/10.1016/0304-3940(95)12168-4.
Bergamaschi S, Binetti G, Govoni S, Wetsel WC, Battaini F, Trabucchi M, et al. Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts. Neurosci Lett. 1995 Dec 1;201(1):1–5.
Bergamaschi, S., et al. “Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts.” Neurosci Lett, vol. 201, no. 1, Dec. 1995, pp. 1–5. Pubmed, doi:10.1016/0304-3940(95)12168-4.
Bergamaschi S, Binetti G, Govoni S, Wetsel WC, Battaini F, Trabucchi M, Bianchetti A, Racchi M. Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts. Neurosci Lett. 1995 Dec 1;201(1):1–5.
Published In
Neurosci Lett
DOI
ISSN
0304-3940
Publication Date
December 1, 1995
Volume
201
Issue
1
Start / End Page
1 / 5
Location
Ireland
Related Subject Headings
- Stimulation, Chemical
- Skin
- Protein Kinase C
- Phorbol 12,13-Dibutyrate
- Middle Aged
- Male
- Isoenzymes
- Humans
- Fibroblasts
- Female