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Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter.

Publication ,  Journal Article
Bossé, R; Fumagalli, F; Jaber, M; Giros, B; Gainetdinov, RR; Wetsel, WC; Missale, C; Caron, MG
Published in: Neuron
July 1997

Deletion of the dopamine transporter (DAT) results in increased dopaminergic tone, anterior pituitary hypoplasia, dwarfism, and an inability to lactate. DAT elimination alters the spatial distribution and dramatically reduces the numbers of lactotrophs and somatotrophs in the pituitary. Despite having normal circulating levels of growth hormone and prolactin in blood, hypoplastic glands from DAT-/- mice fail to respond to secretagog stimulation. The effects of DAT deletion on pituitary function result from elevated DA levels that down-regulate the lactotroph D2 DA receptors and depress hypothalamic growth hormone-releasing hormone content. These results reveal an unexpected and important role or DA in the control of developmental events in the pituitary gland and assign a critical role for hypothalamic DA reuptake in regulating these events.

Duke Scholars

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

July 1997

Volume

19

Issue

1

Start / End Page

127 / 138

Location

United States

Related Subject Headings

  • Pituitary Gland, Anterior
  • Pituitary Diseases
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Mice, Mutant Strains
  • Mice
  • Membrane Transport Proteins
  • Membrane Glycoproteins
  • In Situ Hybridization
  • Hypothalamus
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bossé, R., Fumagalli, F., Jaber, M., Giros, B., Gainetdinov, R. R., Wetsel, W. C., … Caron, M. G. (1997). Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. Neuron, 19(1), 127–138. https://doi.org/10.1016/s0896-6273(00)80353-0
Bossé, R., F. Fumagalli, M. Jaber, B. Giros, R. R. Gainetdinov, W. C. Wetsel, C. Missale, and M. G. Caron. “Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter.Neuron 19, no. 1 (July 1997): 127–38. https://doi.org/10.1016/s0896-6273(00)80353-0.
Bossé R, Fumagalli F, Jaber M, Giros B, Gainetdinov RR, Wetsel WC, et al. Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. Neuron. 1997 Jul;19(1):127–38.
Bossé, R., et al. “Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter.Neuron, vol. 19, no. 1, July 1997, pp. 127–38. Pubmed, doi:10.1016/s0896-6273(00)80353-0.
Bossé R, Fumagalli F, Jaber M, Giros B, Gainetdinov RR, Wetsel WC, Missale C, Caron MG. Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. Neuron. 1997 Jul;19(1):127–138.
Journal cover image

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

July 1997

Volume

19

Issue

1

Start / End Page

127 / 138

Location

United States

Related Subject Headings

  • Pituitary Gland, Anterior
  • Pituitary Diseases
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Mice, Mutant Strains
  • Mice
  • Membrane Transport Proteins
  • Membrane Glycoproteins
  • In Situ Hybridization
  • Hypothalamus