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Midtrimester abortion induced by single intra-amniotic instillation of two dose schedules of 15(S)-15-methyl-prostaglandin F2alpha.

Publication ,  Journal Article
Lauersen, NH; Wilson, KH
Published in: Prostaglandins
April 1975

Midtrimester abortion was successfully induced in a series of 20 patient by intraamniotic instillation of 15(S)-15-methyl-prostaglandin F2alpha with a mean abortion time of 17.78 hours. The patients in this study was divided into two groups, Groups 1 received an initial dose of 2.5 mg 15-ME-PGF2alpha and aborted in a mean time of 16.26 hours. The patients in Group II received 3.0 mg 15-ME-PGF2alpha and aborted in a mean time of 18.94 hours. There was no significant difference in the abortion time, occurrence of side effects or the initiation of uterine activity between Group I and Group II. Parous patients aborted somewhat faster than nulliparous patients but this difference was not significant. In this study 80% of the patients aborted in 24 hours or less, and the intra-amniotic instillation of 15-ME-PGF2alpha was an effective abortifacient technique from the 15th to the 23rd week of gestation. The uterine response to intra-amniotic instillation of 15-ME-PGF2alpha was characterized by the gradual appearance of low amplitude, high frequency contractions accompanied by a rise in baseline intrauterine tonus. Uterine activity developed gradually and peaked at 1:50 hours after intraamniotic instillation of 15-ME-PGF2alpha. In this small series 15-ME-PGF2alpha administered via intra-amniotic instillation did not appear to have a distinct advantage over the naturally occuring PGF2alpha administered by the same method for the induction of midtrimester abortion; a large series in indicated to define the advantage of either technique.

Duke Scholars

Published In

Prostaglandins

DOI

ISSN

0090-6980

Publication Date

April 1975

Volume

9

Issue

4

Start / End Page

617 / 625

Location

United States

Related Subject Headings

  • Vomiting
  • Uterine Contraction
  • Time Factors
  • Prostaglandins F
  • Pressure
  • Pregnancy Trimester, Second
  • Pregnancy
  • Nausea
  • Humans
  • Female
 

Citation

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ICMJE
MLA
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Lauersen, N. H., & Wilson, K. H. (1975). Midtrimester abortion induced by single intra-amniotic instillation of two dose schedules of 15(S)-15-methyl-prostaglandin F2alpha. Prostaglandins, 9(4), 617–625. https://doi.org/10.1016/0090-6980(75)90067-2
Lauersen, N. H., and K. H. Wilson. “Midtrimester abortion induced by single intra-amniotic instillation of two dose schedules of 15(S)-15-methyl-prostaglandin F2alpha.Prostaglandins 9, no. 4 (April 1975): 617–25. https://doi.org/10.1016/0090-6980(75)90067-2.
Lauersen, N. H., and K. H. Wilson. “Midtrimester abortion induced by single intra-amniotic instillation of two dose schedules of 15(S)-15-methyl-prostaglandin F2alpha.Prostaglandins, vol. 9, no. 4, Apr. 1975, pp. 617–25. Pubmed, doi:10.1016/0090-6980(75)90067-2.

Published In

Prostaglandins

DOI

ISSN

0090-6980

Publication Date

April 1975

Volume

9

Issue

4

Start / End Page

617 / 625

Location

United States

Related Subject Headings

  • Vomiting
  • Uterine Contraction
  • Time Factors
  • Prostaglandins F
  • Pressure
  • Pregnancy Trimester, Second
  • Pregnancy
  • Nausea
  • Humans
  • Female