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Postoperative radiosurgery for malignant spinal tumors.

Publication ,  Journal Article
Rock, JP; Ryu, S; Shukairy, MS; Yin, F-F; Sharif, A; Schreiber, F; Abdulhak, M; Kim, JH; Rosenblum, ML
Published in: Neurosurgery
May 2006

OBJECTIVE: Although, as a primary therapy, radiosurgery for spinal tumors is becoming more common in clinical practice and is associated with encouraging clinical results, we wanted to evaluate outcomes after radiosurgery in a series of postoperative patients. METHODS: We examined the medical records of 18 postoperative patients who received radiosurgical treatment to their residual spinal tumors: metastatic carcinoma (10), sarcoma (3), multiple myeloma/plasmacytoma (4), and giant cell tumor (1). Marginal radiosurgical doses ranged from 6 to 16 Gy (mean, 11.4 Gy) prescribed to the 90% isodose line. All regions of the spine received treatment: 2 cervical, 15 thoracic, and 1 lumbosacral. The volume of irradiated spinal elements receiving 30, 50, and 80% of the total dose ranged from 0.51 to 11.05, 0.19 to 6.34, and 0.06 to 1.73 cm, respectively. Treatment sessions (i.e., patient in to patient out of the room) varied between 20 and 40 minutes. Follow-up ranged from 4 to 36 months (median, 7 mo). RESULTS: Even though significant doses of radiation were delivered to all regions of the spinal cord and nerve roots coincidentally involved in the treatments, only one patient in this series developed progressive symptoms possibly attributable to a toxic effect of the radiosurgery. Of those patients initially presenting with neurological deficits, 92% either remained neurologically stable or improved. CONCLUSION: Our observations suggest that radiosurgery as prescribed in this series of postoperative patients with residual spinal tumor is well-tolerated and associated with little to no significant morbidity.

Duke Scholars

Published In

Neurosurgery

DOI

EISSN

1524-4040

Publication Date

May 2006

Volume

58

Issue

5

Start / End Page

891 / 898

Location

United States

Related Subject Headings

  • Spinal Neoplasms
  • Spinal Cord Neoplasms
  • Retrospective Studies
  • Radiosurgery
  • Postoperative Period
  • Neurology & Neurosurgery
  • Middle Aged
  • Humans
  • Aged
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rock, J. P., Ryu, S., Shukairy, M. S., Yin, F.-F., Sharif, A., Schreiber, F., … Rosenblum, M. L. (2006). Postoperative radiosurgery for malignant spinal tumors. Neurosurgery, 58(5), 891–898. https://doi.org/10.1227/01.NEU.0000209913.72761.4F
Rock, Jack P., Samuel Ryu, Mohammad S. Shukairy, Fang-Fang Yin, Aktham Sharif, Faye Schreiber, Muwaffak Abdulhak, Jae Ho Kim, and Mark L. Rosenblum. “Postoperative radiosurgery for malignant spinal tumors.Neurosurgery 58, no. 5 (May 2006): 891–98. https://doi.org/10.1227/01.NEU.0000209913.72761.4F.
Rock JP, Ryu S, Shukairy MS, Yin F-F, Sharif A, Schreiber F, et al. Postoperative radiosurgery for malignant spinal tumors. Neurosurgery. 2006 May;58(5):891–8.
Rock, Jack P., et al. “Postoperative radiosurgery for malignant spinal tumors.Neurosurgery, vol. 58, no. 5, May 2006, pp. 891–98. Pubmed, doi:10.1227/01.NEU.0000209913.72761.4F.
Rock JP, Ryu S, Shukairy MS, Yin F-F, Sharif A, Schreiber F, Abdulhak M, Kim JH, Rosenblum ML. Postoperative radiosurgery for malignant spinal tumors. Neurosurgery. 2006 May;58(5):891–898.
Journal cover image

Published In

Neurosurgery

DOI

EISSN

1524-4040

Publication Date

May 2006

Volume

58

Issue

5

Start / End Page

891 / 898

Location

United States

Related Subject Headings

  • Spinal Neoplasms
  • Spinal Cord Neoplasms
  • Retrospective Studies
  • Radiosurgery
  • Postoperative Period
  • Neurology & Neurosurgery
  • Middle Aged
  • Humans
  • Aged
  • Adult