Skip to main content
Journal cover image

Influence of coronary artery disease and coronary revascularization status on outcomes in patients with acute heart failure syndromes: a report from OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure).

Publication ,  Journal Article
Rossi, JS; Flaherty, JD; Fonarow, GC; Nunez, E; Gattis Stough, W; Abraham, WT; Albert, NM; Greenberg, BH; O'Connor, CM; Yancy, CW; Young, JB ...
Published in: Eur J Heart Fail
December 2008

BACKGROUND: Coronary artery disease (CAD) is frequent among patients hospitalized with acute heart failure syndromes (AHFS). AIMS: To describe the influence of coronary revascularization status on survival in patients with AHFS. METHODS AND RESULTS: OPTIMIZE-HF enrolled 48,612 patients with AHFS from 259 U.S. hospitals. In-hospital data were obtained for all patients and post-discharge 60-90 day follow-up in a pre-specified 10% sample. CAD was associated with higher in-hospital (3.7% vs. 2.9%, OR 1.14, 95% CI 1.00-1.31) and post-discharge mortality (9.2% vs. 6.9%, HR 1.37, 95% CI 1.03-1.81) compared to no CAD. Post-discharge, patients with CAD who were not revascularized had higher mortality compared to patients without CAD (10.6% vs. 6.9%, HR 1.56, 95% CI 1.15-2.11). This association was similar in patients with left ventricular systolic dysfunction (EF <40%, adjusted HR 1.52, 95% CI 0.98-2.35) and preserved systolic function (EF > or =40%, adjusted HR1.58, 95% CI 1.05-2.39). Patients with CAD who were revascularized had similar mortality to patients without CAD (HR 1.06, 95% CI 0.62-1.80 for PSF, HR 1.13, 95% CI 0.71-1.80 for LVSD). CONCLUSIONS: In AHFS, patients with CAD have a higher 60-90 day post-discharge mortality compared to no-CAD patients. However, patients with CAD who are revascularized appear to have similar post-discharge mortality when compared to the no-CAD group. This suggests that revascularization status may confer a survival advantage in this high risk population.

Duke Scholars

Published In

Eur J Heart Fail

DOI

ISSN

1388-9842

Publication Date

December 2008

Volume

10

Issue

12

Start / End Page

1215 / 1223

Location

England

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Treatment Outcome
  • Syndrome
  • Risk Factors
  • Retrospective Studies
  • Program Development
  • Prognosis
  • Odds Ratio
  • Myocardial Revascularization
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rossi, J. S., Flaherty, J. D., Fonarow, G. C., Nunez, E., Gattis Stough, W., Abraham, W. T., … Gheorghiade, M. (2008). Influence of coronary artery disease and coronary revascularization status on outcomes in patients with acute heart failure syndromes: a report from OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure). Eur J Heart Fail, 10(12), 1215–1223. https://doi.org/10.1016/j.ejheart.2008.09.009
Rossi, Joseph S., James D. Flaherty, Gregg C. Fonarow, Eduardo Nunez, Wendy Gattis Stough, William T. Abraham, Nancy M. Albert, et al. “Influence of coronary artery disease and coronary revascularization status on outcomes in patients with acute heart failure syndromes: a report from OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure).Eur J Heart Fail 10, no. 12 (December 2008): 1215–23. https://doi.org/10.1016/j.ejheart.2008.09.009.
Rossi JS, Flaherty JD, Fonarow GC, Nunez E, Gattis Stough W, Abraham WT, Albert NM, Greenberg BH, O’Connor CM, Yancy CW, Young JB, Davidson CJ, Gheorghiade M. Influence of coronary artery disease and coronary revascularization status on outcomes in patients with acute heart failure syndromes: a report from OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure). Eur J Heart Fail. 2008 Dec;10(12):1215–1223.
Journal cover image

Published In

Eur J Heart Fail

DOI

ISSN

1388-9842

Publication Date

December 2008

Volume

10

Issue

12

Start / End Page

1215 / 1223

Location

England

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Treatment Outcome
  • Syndrome
  • Risk Factors
  • Retrospective Studies
  • Program Development
  • Prognosis
  • Odds Ratio
  • Myocardial Revascularization
  • Male