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Arc-modulated radiation therapy based on linear models.

Publication ,  Journal Article
Zhu, X; Thongphiew, D; McMahon, R; Li, T; Chankong, V; Yin, F-F; Wu, QJ
Published in: Phys Med Biol
July 7, 2010

This paper reports an inverse arc-modulated radiation therapy planning technique based on linear models. It is implemented with a two-step procedure. First, fluence maps for 36 fixed-gantry beams are generated using a linear model-based intensity-modulated radiation therapy (IMRT) optimization algorithm. The 2D fluence maps are decomposed into 1D fluence profiles according to each leaf pair position. Second, a mixed integer linear model is used to construct the leaf motions of an arc delivery that reproduce the 1D fluence profile previously derived from the static gantry IMRT optimization. The multi-leaf collimator (MLC) sequence takes into account the starting and ending leaf positions in between the neighbouring apertures, such that the MLC segments of the entire treatment plan are deliverable in a continuous arc. Since both steps in the algorithm use linear models, implementation is simple and straightforward. Details of the algorithm are presented, and its conceptual correctness is verified with clinical cases representing prostate and head-and-neck treatments.

Duke Scholars

Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

July 7, 2010

Volume

55

Issue

13

Start / End Page

3873 / 3883

Location

England

Related Subject Headings

  • Seminal Vesicles
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy
  • Radiation Dosage
  • Prostatic Neoplasms
  • Prostate
  • Nuclear Medicine & Medical Imaging
  • Neck
  • Male
 

Citation

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Zhu, X., Thongphiew, D., McMahon, R., Li, T., Chankong, V., Yin, F.-F., & Wu, Q. J. (2010). Arc-modulated radiation therapy based on linear models. Phys Med Biol, 55(13), 3873–3883. https://doi.org/10.1088/0031-9155/55/13/020
Zhu, Xiaofeng, Danthai Thongphiew, Ryan McMahon, Taoran Li, Vira Chankong, Fang-Fang Yin, and Q Jackie Wu. “Arc-modulated radiation therapy based on linear models.Phys Med Biol 55, no. 13 (July 7, 2010): 3873–83. https://doi.org/10.1088/0031-9155/55/13/020.
Zhu X, Thongphiew D, McMahon R, Li T, Chankong V, Yin F-F, et al. Arc-modulated radiation therapy based on linear models. Phys Med Biol. 2010 Jul 7;55(13):3873–83.
Zhu, Xiaofeng, et al. “Arc-modulated radiation therapy based on linear models.Phys Med Biol, vol. 55, no. 13, July 2010, pp. 3873–83. Pubmed, doi:10.1088/0031-9155/55/13/020.
Zhu X, Thongphiew D, McMahon R, Li T, Chankong V, Yin F-F, Wu QJ. Arc-modulated radiation therapy based on linear models. Phys Med Biol. 2010 Jul 7;55(13):3873–3883.
Journal cover image

Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

July 7, 2010

Volume

55

Issue

13

Start / End Page

3873 / 3883

Location

England

Related Subject Headings

  • Seminal Vesicles
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy
  • Radiation Dosage
  • Prostatic Neoplasms
  • Prostate
  • Nuclear Medicine & Medical Imaging
  • Neck
  • Male