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The investigation on the location effect of external markers in respiratory-gated radiotherapy.

Publication ,  Journal Article
Yan, H; Zhu, G; Yang, J; Lu, M; Ajlouni, M; Kim, JH; Yin, F-F
Published in: J Appl Clin Med Phys
April 16, 2008

PURPOSE: To investigate the effect of the marker placement on the correlation relationship between the motions of external markers and the internal target under different breathing patterns for several lung cancer patients. METHOD AND MATERIAL: To monitor and record simultaneous motions of internal target and associated surrogate markers during respiratory gated radiotherapy, an infrared camera system synchronized with a medical simulator was installed in our institute. Multiple external markers were placed on the patients' chest wall with proper geometrical arrangement in closely monitoring the motion of skin near tumor. The motion signals of three breathing sessions (free breathing, breath-holding, and free breathing after breath-holding) were recorded and the quality of correlation between them was analyzed. For a single marker motion, its correlation with the internal target was analyzed using cross-covariance function. For the multiple markers, their correlation with the internal target was analyzed based on additive model. RESULT: Seven patients undergoing radiotherapy with right upper or middle lobe lesions were enrolled in this study. Statistic analysis based on the internal-external motion signals shows that the effect of marker location on the quality of its correlation with the internal target is varied from patient to patient. There was no specific marker location where consistently demonstrated superior quality of correlation with the internal target motion over three breathing sessions for all patients. As the composite surrogate signal which was generated from the motions of multiple external markers was used to correlate the internal target motion, significant improvement of the quality of correlation was achieved. CONCLUSION: The correlation of external marker to the internal target could be influenced by several factors such as patient population, marker locations, and breathing patterns, considerably. The quality of correlation and predictability to the internal target furnished by a single external marker is inferior to that of the composite signal generated from multiple external markers. The use of composite signal shows great potential in improving the predictability of internal target motion and presents an effective way to track tumor more accurately.

Duke Scholars

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Published In

J Appl Clin Med Phys

DOI

EISSN

1526-9914

Publication Date

April 16, 2008

Volume

9

Issue

2

Start / End Page

57 / 68

Location

United States

Related Subject Headings

  • Respiration
  • Radiotherapy Planning, Computer-Assisted
  • Nuclear Medicine & Medical Imaging
  • Movement
  • Middle Aged
  • Lung Neoplasms
  • Humans
  • Female
  • Carcinoma, Squamous Cell
  • Breast Neoplasms
 

Citation

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Yan, H., Zhu, G., Yang, J., Lu, M., Ajlouni, M., Kim, J. H., & Yin, F.-F. (2008). The investigation on the location effect of external markers in respiratory-gated radiotherapy. J Appl Clin Med Phys, 9(2), 57–68. https://doi.org/10.1120/jacmp.v9i2.2758
Yan, Hui, Guopei Zhu, James Yang, Mei Lu, Munther Ajlouni, Jae Ho Kim, and Fang-Fang Yin. “The investigation on the location effect of external markers in respiratory-gated radiotherapy.J Appl Clin Med Phys 9, no. 2 (April 16, 2008): 57–68. https://doi.org/10.1120/jacmp.v9i2.2758.
Yan H, Zhu G, Yang J, Lu M, Ajlouni M, Kim JH, et al. The investigation on the location effect of external markers in respiratory-gated radiotherapy. J Appl Clin Med Phys. 2008 Apr 16;9(2):57–68.
Yan, Hui, et al. “The investigation on the location effect of external markers in respiratory-gated radiotherapy.J Appl Clin Med Phys, vol. 9, no. 2, Apr. 2008, pp. 57–68. Pubmed, doi:10.1120/jacmp.v9i2.2758.
Yan H, Zhu G, Yang J, Lu M, Ajlouni M, Kim JH, Yin F-F. The investigation on the location effect of external markers in respiratory-gated radiotherapy. J Appl Clin Med Phys. 2008 Apr 16;9(2):57–68.

Published In

J Appl Clin Med Phys

DOI

EISSN

1526-9914

Publication Date

April 16, 2008

Volume

9

Issue

2

Start / End Page

57 / 68

Location

United States

Related Subject Headings

  • Respiration
  • Radiotherapy Planning, Computer-Assisted
  • Nuclear Medicine & Medical Imaging
  • Movement
  • Middle Aged
  • Lung Neoplasms
  • Humans
  • Female
  • Carcinoma, Squamous Cell
  • Breast Neoplasms