Skip to main content

Head and neck cancer as a model for advances in imaging prognosis, early assessment, and posttherapy evaluation.

Publication ,  Journal Article
Brizel, DM
Published in: Cancer J
2011

Novel noninvasive functional imaging methods are necessary to predict therapeutic outcome and thereby improve the ability to properly select patients for treatment with both conventional and targeted therapies, to better evaluate therapeutic effectiveness during the early phases of treatment, and to enhance a priori risk assessment for treatment induced toxicity. Functional metabolic imaging typically involves pretreatment baseline magnetic resonance imaging (MRI) and/or positron emission tomographic (PET) scans and performance of subsequent scans during and/or after treatment. Imaging parameter changes are routinely attributed to the intervening therapy and clinical outcomes subsequently correlated with these changes. The physiologic parameter(s) that best correlate with clinical outcome and the relative utility of MRI versus PET are unknown, however. Furthermore, tumor vascular physiology and metabolic parameters are heterogeneous and dynamic processes. Large daily fluctuations often occur in the absence of treatment. The magnitude of this temporal variability is not established for MRI or for PET. Routine and meaningful clinical application of functional imaging requires understanding and quantification of the intrinsic variability of the underlying biologic processes and a demonstration that treatment-induced changes exceed intrinsic temporal variation.

Duke Scholars

Published In

Cancer J

DOI

EISSN

1540-336X

Publication Date

2011

Volume

17

Issue

3

Start / End Page

159 / 165

Location

United States

Related Subject Headings

  • Prognosis
  • Positron-Emission Tomography
  • Oncology & Carcinogenesis
  • Magnetic Resonance Imaging
  • Humans
  • Head and Neck Neoplasms
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Brizel, D. M. (2011). Head and neck cancer as a model for advances in imaging prognosis, early assessment, and posttherapy evaluation. Cancer J, 17(3), 159–165. https://doi.org/10.1097/PPO.0b013e31821e8a09
Brizel, David M. “Head and neck cancer as a model for advances in imaging prognosis, early assessment, and posttherapy evaluation.Cancer J 17, no. 3 (2011): 159–65. https://doi.org/10.1097/PPO.0b013e31821e8a09.
Brizel, David M. “Head and neck cancer as a model for advances in imaging prognosis, early assessment, and posttherapy evaluation.Cancer J, vol. 17, no. 3, 2011, pp. 159–65. Pubmed, doi:10.1097/PPO.0b013e31821e8a09.

Published In

Cancer J

DOI

EISSN

1540-336X

Publication Date

2011

Volume

17

Issue

3

Start / End Page

159 / 165

Location

United States

Related Subject Headings

  • Prognosis
  • Positron-Emission Tomography
  • Oncology & Carcinogenesis
  • Magnetic Resonance Imaging
  • Humans
  • Head and Neck Neoplasms
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis