Skip to main content
release_alert
Welcome to the new Scholars 3.0! Read about new features and let us know what you think.
cancel

Adaptive evolution: evaluating empirical support for theoretical predictions.

Publication ,  Journal Article
Olson-Manning, CF; Wagner, MR; Mitchell-Olds, T
Published in: Nature Reviews. Genetics
December 2012

Adaptive evolution is shaped by the interaction of population genetics, natural selection and underlying network and biochemical constraints. Variation created by mutation, the raw material for evolutionary change, is translated into phenotypes by flux through metabolic pathways and by the topography and dynamics of molecular networks. Finally, the retention of genetic variation and the efficacy of selection depend on population genetics and demographic history. Emergent high-throughput experimental methods and sequencing technologies allow us to gather more evidence and to move beyond the theory in different systems and populations. Here we review the extent to which recent evidence supports long-established theoretical principles of adaptation.

Duke Scholars

Published In

Nature Reviews. Genetics

DOI

EISSN

1471-0064

ISSN

1471-0056

Publication Date

December 2012

Volume

13

Issue

12

Start / End Page

867 / 877

Related Subject Headings

  • Selection, Genetic
  • Recombination, Genetic
  • Mutation
  • Models, Genetic
  • Humans
  • Genetics, Population
  • Gene Regulatory Networks
  • Gene Flow
  • Evolution, Molecular
  • Epistasis, Genetic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Olson-Manning, C. F., Wagner, M. R., & Mitchell-Olds, T. (2012). Adaptive evolution: evaluating empirical support for theoretical predictions. Nature Reviews. Genetics, 13(12), 867–877. https://doi.org/10.1038/nrg3322
Olson-Manning, Carrie F., Maggie R. Wagner, and Thomas Mitchell-Olds. “Adaptive evolution: evaluating empirical support for theoretical predictions.Nature Reviews. Genetics 13, no. 12 (December 2012): 867–77. https://doi.org/10.1038/nrg3322.
Olson-Manning CF, Wagner MR, Mitchell-Olds T. Adaptive evolution: evaluating empirical support for theoretical predictions. Nature Reviews Genetics. 2012 Dec;13(12):867–77.
Olson-Manning, Carrie F., et al. “Adaptive evolution: evaluating empirical support for theoretical predictions.Nature Reviews. Genetics, vol. 13, no. 12, Dec. 2012, pp. 867–77. Epmc, doi:10.1038/nrg3322.
Olson-Manning CF, Wagner MR, Mitchell-Olds T. Adaptive evolution: evaluating empirical support for theoretical predictions. Nature Reviews Genetics. 2012 Dec;13(12):867–877.

Published In

Nature Reviews. Genetics

DOI

EISSN

1471-0064

ISSN

1471-0056

Publication Date

December 2012

Volume

13

Issue

12

Start / End Page

867 / 877

Related Subject Headings

  • Selection, Genetic
  • Recombination, Genetic
  • Mutation
  • Models, Genetic
  • Humans
  • Genetics, Population
  • Gene Regulatory Networks
  • Gene Flow
  • Evolution, Molecular
  • Epistasis, Genetic