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A gain-of-function polymorphism controlling complex traits and fitness in nature.

Publication ,  Journal Article
Prasad, KVSK; Song, B-H; Olson-Manning, C; Anderson, JT; Lee, C-R; Schranz, ME; Windsor, AJ; Clauss, MJ; Manzaneda, AJ; Naqvi, I; Reichelt, M ...
Published in: Science (New York, N.Y.)
August 2012

Identification of the causal genes that control complex trait variation remains challenging, limiting our appreciation of the evolutionary processes that influence polymorphisms in nature. We cloned a quantitative trait locus that controls plant defensive chemistry, damage by insect herbivores, survival, and reproduction in the natural environments where this polymorphism evolved. These ecological effects are driven by duplications in the BCMA (branched-chain methionine allocation) loci controlling this variation and by two selectively favored amino acid changes in the glucosinolate-biosynthetic cytochrome P450 proteins that they encode. These changes cause a gain of novel enzyme function, modulated by allelic differences in catalytic rate and gene copy number. Ecological interactions in diverse environments likely contribute to the widespread polymorphism of this biochemical function.

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Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

August 2012

Volume

337

Issue

6098

Start / End Page

1081 / 1084

Related Subject Headings

  • Selection, Genetic
  • Quantitative Trait, Heritable
  • Quantitative Trait Loci
  • Polymorphism, Genetic
  • Plants, Genetically Modified
  • Plant Leaves
  • Molecular Sequence Data
  • Methionine
  • Herbivory
  • Glucosinolates
 

Citation

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Prasad, K. V. S. K., Song, B.-H., Olson-Manning, C., Anderson, J. T., Lee, C.-R., Schranz, M. E., … Mitchell-Olds, T. (2012). A gain-of-function polymorphism controlling complex traits and fitness in nature. Science (New York, N.Y.), 337(6098), 1081–1084. https://doi.org/10.1126/science.1221636
Prasad, Kasavajhala V. S. K., Bao-Hua Song, Carrie Olson-Manning, Jill T. Anderson, Cheng-Ruei Lee, M Eric Schranz, Aaron J. Windsor, et al. “A gain-of-function polymorphism controlling complex traits and fitness in nature.Science (New York, N.Y.) 337, no. 6098 (August 2012): 1081–84. https://doi.org/10.1126/science.1221636.
Prasad KVSK, Song B-H, Olson-Manning C, Anderson JT, Lee C-R, Schranz ME, et al. A gain-of-function polymorphism controlling complex traits and fitness in nature. Science (New York, NY). 2012 Aug;337(6098):1081–4.
Prasad, Kasavajhala V. S. K., et al. “A gain-of-function polymorphism controlling complex traits and fitness in nature.Science (New York, N.Y.), vol. 337, no. 6098, Aug. 2012, pp. 1081–84. Epmc, doi:10.1126/science.1221636.
Prasad KVSK, Song B-H, Olson-Manning C, Anderson JT, Lee C-R, Schranz ME, Windsor AJ, Clauss MJ, Manzaneda AJ, Naqvi I, Reichelt M, Gershenzon J, Rupasinghe SG, Schuler MA, Mitchell-Olds T. A gain-of-function polymorphism controlling complex traits and fitness in nature. Science (New York, NY). 2012 Aug;337(6098):1081–1084.
Journal cover image

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

August 2012

Volume

337

Issue

6098

Start / End Page

1081 / 1084

Related Subject Headings

  • Selection, Genetic
  • Quantitative Trait, Heritable
  • Quantitative Trait Loci
  • Polymorphism, Genetic
  • Plants, Genetically Modified
  • Plant Leaves
  • Molecular Sequence Data
  • Methionine
  • Herbivory
  • Glucosinolates