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Intracellular Neural Recording with Pure Carbon Nanotube Probes.

Publication ,  Journal Article
Yoon, I; Hamaguchi, K; Borzenets, IV; Finkelstein, G; Mooney, R; Donald, BR
Published in: PLoS One
2013

The computational complexity of the brain depends in part on a neuron's capacity to integrate electrochemical information from vast numbers of synaptic inputs. The measurements of synaptic activity that are crucial for mechanistic understanding of brain function are also challenging, because they require intracellular recording methods to detect and resolve millivolt- scale synaptic potentials. Although glass electrodes are widely used for intracellular recordings, novel electrodes with superior mechanical and electrical properties are desirable, because they could extend intracellular recording methods to challenging environments, including long term recordings in freely behaving animals. Carbon nanotubes (CNTs) can theoretically deliver this advance, but the difficulty of assembling CNTs has limited their application to a coating layer or assembly on a planar substrate, resulting in electrodes that are more suitable for in vivo extracellular recording or extracellular recording from isolated cells. Here we show that a novel, yet remarkably simple, millimeter-long electrode with a sub-micron tip, fabricated from self-entangled pure CNTs can be used to obtain intracellular and extracellular recordings from vertebrate neurons in vitro and in vivo. This fabrication technology provides a new method for assembling intracellular electrodes from CNTs, affording a promising opportunity to harness nanotechnology for neuroscience applications.

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

6

Start / End Page

e65715

Location

United States

Related Subject Headings

  • Vertebrates
  • Synapses
  • Neurons
  • Nanotubes, Carbon
  • Nanotechnology
  • Microelectrodes
  • Mice
  • General Science & Technology
  • Equipment Failure Analysis
  • Equipment Design
 

Citation

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Yoon, I., Hamaguchi, K., Borzenets, I. V., Finkelstein, G., Mooney, R., & Donald, B. R. (2013). Intracellular Neural Recording with Pure Carbon Nanotube Probes. PLoS One, 8(6), e65715. https://doi.org/10.1371/journal.pone.0065715
Yoon, Inho, Kosuke Hamaguchi, Ivan V. Borzenets, Gleb Finkelstein, Richard Mooney, and Bruce R. Donald. “Intracellular Neural Recording with Pure Carbon Nanotube Probes.PLoS One 8, no. 6 (2013): e65715. https://doi.org/10.1371/journal.pone.0065715.
Yoon I, Hamaguchi K, Borzenets IV, Finkelstein G, Mooney R, Donald BR. Intracellular Neural Recording with Pure Carbon Nanotube Probes. PLoS One. 2013;8(6):e65715.
Yoon, Inho, et al. “Intracellular Neural Recording with Pure Carbon Nanotube Probes.PLoS One, vol. 8, no. 6, 2013, p. e65715. Pubmed, doi:10.1371/journal.pone.0065715.
Yoon I, Hamaguchi K, Borzenets IV, Finkelstein G, Mooney R, Donald BR. Intracellular Neural Recording with Pure Carbon Nanotube Probes. PLoS One. 2013;8(6):e65715.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

6

Start / End Page

e65715

Location

United States

Related Subject Headings

  • Vertebrates
  • Synapses
  • Neurons
  • Nanotubes, Carbon
  • Nanotechnology
  • Microelectrodes
  • Mice
  • General Science & Technology
  • Equipment Failure Analysis
  • Equipment Design