Skip to main content

CD4 T follicular helper cell dynamics during SIV infection.

Publication ,  Journal Article
Petrovas, C; Yamamoto, T; Gerner, MY; Boswell, KL; Wloka, K; Smith, EC; Ambrozak, DR; Sandler, NG; Timmer, KJ; Sun, X; Pan, L; Poholek, A ...
Published in: J Clin Invest
September 2012

CD4 T follicular helper (TFH) cells interact with and stimulate the generation of antigen-specific B cells. TFH cell interaction with B cells correlates with production of SIV-specific immunoglobulins. However, the fate of TFH cells and their participation in SIV-induced antibody production is not well understood. We investigated the phenotype, function, location, and molecular signature of TFH cells in rhesus macaques. Similar to their human counterparts, TFH cells in rhesus macaques represented a heterogeneous population with respect to cytokine function. In a highly differentiated subpopulation of TFH cells, characterized by CD150lo expression, production of Th1 cytokines was compromised while IL-4 production was augmented, and cells exhibited decreased survival, cycling, and trafficking capacity. TFH cells exhibited a distinct gene profile that was markedly altered by SIV infection. TFH cells were infected by SIV; yet, in some animals, these cells actually accumulated during chronic SIV infection. Generalized immune activation and increased IL-6 production helped drive TFH differentiation during SIV infection. Accumulation of TFH cells was associated with increased frequency of activated germinal center B cells and SIV-specific antibodies. Therefore, chronic SIV does not disturb the ability of TFH cells to help B cell maturation and production of SIV-specific immunoglobulins.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

September 2012

Volume

122

Issue

9

Start / End Page

3281 / 3294

Location

United States

Related Subject Headings

  • Transcriptome
  • Transcription Factors
  • T-Lymphocytes, Helper-Inducer
  • T-Box Domain Proteins
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Receptors, Lysosphingolipid
  • Proto-Oncogene Proteins c-maf
  • Oligonucleotide Array Sequence Analysis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Petrovas, C., Yamamoto, T., Gerner, M. Y., Boswell, K. L., Wloka, K., Smith, E. C., … Koup, R. A. (2012). CD4 T follicular helper cell dynamics during SIV infection. J Clin Invest, 122(9), 3281–3294. https://doi.org/10.1172/JCI63039
Petrovas, Constantinos, Takuya Yamamoto, Michael Y. Gerner, Kristin L. Boswell, Kaska Wloka, Emily C. Smith, David R. Ambrozak, et al. “CD4 T follicular helper cell dynamics during SIV infection.J Clin Invest 122, no. 9 (September 2012): 3281–94. https://doi.org/10.1172/JCI63039.
Petrovas C, Yamamoto T, Gerner MY, Boswell KL, Wloka K, Smith EC, et al. CD4 T follicular helper cell dynamics during SIV infection. J Clin Invest. 2012 Sep;122(9):3281–94.
Petrovas, Constantinos, et al. “CD4 T follicular helper cell dynamics during SIV infection.J Clin Invest, vol. 122, no. 9, Sept. 2012, pp. 3281–94. Pubmed, doi:10.1172/JCI63039.
Petrovas C, Yamamoto T, Gerner MY, Boswell KL, Wloka K, Smith EC, Ambrozak DR, Sandler NG, Timmer KJ, Sun X, Pan L, Poholek A, Rao SS, Brenchley JM, Alam SM, Tomaras GD, Roederer M, Douek DC, Seder RA, Germain RN, Haddad EK, Koup RA. CD4 T follicular helper cell dynamics during SIV infection. J Clin Invest. 2012 Sep;122(9):3281–3294.

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

September 2012

Volume

122

Issue

9

Start / End Page

3281 / 3294

Location

United States

Related Subject Headings

  • Transcriptome
  • Transcription Factors
  • T-Lymphocytes, Helper-Inducer
  • T-Box Domain Proteins
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Receptors, Lysosphingolipid
  • Proto-Oncogene Proteins c-maf
  • Oligonucleotide Array Sequence Analysis