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UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts.

Publication ,  Journal Article
Bess, AS; Ryde, IT; Hinton, DE; Meyer, JN
Published in: Journal of biochemical and molecular toxicology
January 2013

Mitochondrial DNA (mtDNA) is more susceptible than nuclear DNA to helix-distorting damage via exposure to environmental genotoxins, partially due to a lack of nucleotide excision repair. Thus, this damage is irreparable and persistent in mtDNA in the short term. We recently found that helix-distorting mtDNA damage induced by ultraviolet C radiation (UVC) is gradually removed in Caenorhabditis elegans and that removal is dependent upon autophagy and mitochondrial dynamics. We here report the effects of UVC exposure on mitophagy, mitochondrial morphology, and indicators of mitochondrial function in mammalian cells. Exposure to UVC induced autophagy within 24 h; nonetheless, significant mitochondrial degradation was not observed until 72 h post exposure. Mitochondrial mass, morphology, and function were not significantly altered. These data further support the idea that persistent mtDNA damage is removed by autophagy and also suggest a powerful compensatory capacity for dealing with mtDNA damage.

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Published In

Journal of biochemical and molecular toxicology

DOI

EISSN

1099-0461

ISSN

1095-6670

Publication Date

January 2013

Volume

27

Issue

1

Start / End Page

28 / 41

Related Subject Headings

  • Ultraviolet Rays
  • Toxicology
  • Time Factors
  • Reactive Oxygen Species
  • Mitochondria
  • Membrane Potential, Mitochondrial
  • Lysosomes
  • Humans
  • Fibroblasts
  • DNA, Mitochondrial
 

Citation

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Bess, A. S., Ryde, I. T., Hinton, D. E., & Meyer, J. N. (2013). UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts. Journal of Biochemical and Molecular Toxicology, 27(1), 28–41. https://doi.org/10.1002/jbt.21440
Bess, Amanda S., Ian T. Ryde, David E. Hinton, and Joel N. Meyer. “UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts.Journal of Biochemical and Molecular Toxicology 27, no. 1 (January 2013): 28–41. https://doi.org/10.1002/jbt.21440.
Bess AS, Ryde IT, Hinton DE, Meyer JN. UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts. Journal of biochemical and molecular toxicology. 2013 Jan;27(1):28–41.
Bess, Amanda S., et al. “UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts.Journal of Biochemical and Molecular Toxicology, vol. 27, no. 1, Jan. 2013, pp. 28–41. Epmc, doi:10.1002/jbt.21440.
Bess AS, Ryde IT, Hinton DE, Meyer JN. UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts. Journal of biochemical and molecular toxicology. 2013 Jan;27(1):28–41.
Journal cover image

Published In

Journal of biochemical and molecular toxicology

DOI

EISSN

1099-0461

ISSN

1095-6670

Publication Date

January 2013

Volume

27

Issue

1

Start / End Page

28 / 41

Related Subject Headings

  • Ultraviolet Rays
  • Toxicology
  • Time Factors
  • Reactive Oxygen Species
  • Mitochondria
  • Membrane Potential, Mitochondrial
  • Lysosomes
  • Humans
  • Fibroblasts
  • DNA, Mitochondrial