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Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model.

Publication ,  Journal Article
Obeid, R; Hartmuth, K; Herrmann, W; Gortner, L; Rohrer, TR; Geisel, J; Reed, MC; Nijhout, HF
Published in: Molecular nutrition & food research
October 2012

The study tests the metabolites of the methylation cycle in individuals with Down syndrome (DS) and applies a mathematical model in order to change this cycle by nutritional factors.We measured concentrations of the metabolites related to the methylation cycle in the blood of 35 young individuals with DS and 47 controls of comparable age. Moreover, we applied a mathematical model to learn more about the regulation of the methylation cycle in DS. Concentrations of cystathionine, cysteine, betaine, choline, dimethylglycine, S-adenosylhomocysteine (SAH), S-adenosylmethionine (SAM), and holotranscobalamin were significantly higher in DS compared to the controls. The median SAM/SAH ratio was lower in DS and that of methionine and reduced glutathione did not differ significantly between the groups. The mathematical model showed that enhanced methionine turnover and accelerated Hcy-remethylation might explain the shift in the methylation cycle in DS.In addition to the DS-related excess of cystathionine beta synthase (CBS) activity, increases in the activities of MS and betaine homocysteine methyl transferase, and in methionine input were necessary to account for the changes in metabolite levels observed in DS. A low-methionine diet might offer a perspective for reversing the metabolic imbalance in DS, but this awaits clinical investigations.

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Published In

Molecular nutrition & food research

DOI

EISSN

1613-4133

ISSN

1613-4125

Publication Date

October 2012

Volume

56

Issue

10

Start / End Page

1582 / 1589

Related Subject Headings

  • Young Adult
  • Sarcosine
  • S-Adenosylmethionine
  • S-Adenosylhomocysteine
  • Nutrition & Dietetics
  • Models, Theoretical
  • Methylation
  • Methionine
  • Male
  • Infant
 

Citation

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Obeid, R., Hartmuth, K., Herrmann, W., Gortner, L., Rohrer, T. R., Geisel, J., … Nijhout, H. F. (2012). Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model. Molecular Nutrition & Food Research, 56(10), 1582–1589. https://doi.org/10.1002/mnfr.201200162
Obeid, Rima, Kathrin Hartmuth, Wolfgang Herrmann, Ludwig Gortner, Tilman R. Rohrer, Jürgen Geisel, Michael C. Reed, and H Frederik Nijhout. “Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model.Molecular Nutrition & Food Research 56, no. 10 (October 2012): 1582–89. https://doi.org/10.1002/mnfr.201200162.
Obeid R, Hartmuth K, Herrmann W, Gortner L, Rohrer TR, Geisel J, et al. Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model. Molecular nutrition & food research. 2012 Oct;56(10):1582–9.
Obeid, Rima, et al. “Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model.Molecular Nutrition & Food Research, vol. 56, no. 10, Oct. 2012, pp. 1582–89. Epmc, doi:10.1002/mnfr.201200162.
Obeid R, Hartmuth K, Herrmann W, Gortner L, Rohrer TR, Geisel J, Reed MC, Nijhout HF. Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model. Molecular nutrition & food research. 2012 Oct;56(10):1582–1589.
Journal cover image

Published In

Molecular nutrition & food research

DOI

EISSN

1613-4133

ISSN

1613-4125

Publication Date

October 2012

Volume

56

Issue

10

Start / End Page

1582 / 1589

Related Subject Headings

  • Young Adult
  • Sarcosine
  • S-Adenosylmethionine
  • S-Adenosylhomocysteine
  • Nutrition & Dietetics
  • Models, Theoretical
  • Methylation
  • Methionine
  • Male
  • Infant