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Genetics in population health science: strategies and opportunities

Publication ,  Journal Article
Belsky, DW; Moffitt, TE; Caspi, A
Published in: American journal of public health
October 2013

Translational research is needed to leverage discoveries from the frontiers of genome science to improve public health. So far, public health researchers have largely ignored genetic discoveries, and geneticists have ignored important aspects of population health science. This mutual neglect should end. In this article, we discuss 3 areas where public health researchers can help to advance translation: (1) risk assessment: investigate genetic profiles as components in composite risk assessments; (2) targeted intervention: conduct life-course longitudinal studies to understand when genetic risks manifest in development and whether intervention during sensitive periods can have lasting effects; and (3) improved understanding of environmental causation: collaborate with geneticists on gene-environment interaction research. We illustrate with examples from our own research on obesity and smoking.

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Published In

American journal of public health

DOI

ISSN

1541-0048

Publication Date

October 2013

Volume

103 Suppl 1

Start / End Page

S73 / 83

Related Subject Headings

  • Translational Research, Biomedical
  • Smoking
  • Risk Assessment
  • Public Health
  • Public Health
  • Obesity
  • Humans
  • Genetic Research
  • Genetic Engineering
  • Gene-Environment Interaction
 

Citation

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Chicago
ICMJE
MLA
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Belsky, D. W., Moffitt, T. E., & Caspi, A. (2013). Genetics in population health science: strategies and opportunities. American Journal of Public Health, 103 Suppl 1, S73-83. https://doi.org/10.2105/AJPH.2012.301139
Belsky, Daniel W., Terrie E. Moffitt, and Avshalom Caspi. “Genetics in population health science: strategies and opportunities.” American Journal of Public Health 103 Suppl 1 (October 2013): S73-83. https://doi.org/10.2105/AJPH.2012.301139.
Belsky DW, Moffitt TE, Caspi A. Genetics in population health science: strategies and opportunities. American journal of public health. 2013 Oct;103 Suppl 1:S73-83.
Belsky, Daniel W., et al. “Genetics in population health science: strategies and opportunities.” American Journal of Public Health, vol. 103 Suppl 1, Oct. 2013, pp. S73-83. Manual, doi:10.2105/AJPH.2012.301139.
Belsky DW, Moffitt TE, Caspi A. Genetics in population health science: strategies and opportunities. American journal of public health. 2013 Oct;103 Suppl 1:S73-83.

Published In

American journal of public health

DOI

ISSN

1541-0048

Publication Date

October 2013

Volume

103 Suppl 1

Start / End Page

S73 / 83

Related Subject Headings

  • Translational Research, Biomedical
  • Smoking
  • Risk Assessment
  • Public Health
  • Public Health
  • Obesity
  • Humans
  • Genetic Research
  • Genetic Engineering
  • Gene-Environment Interaction