
Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs.
Publication
, Journal Article
Razdan, RK; Handrick, GR; Dalzell, HC; Howes, JF; Winn, M; Plotnikoff, NP; Dodge, PW; Dren, AT
Published in: Journal of Medicinal Chemistry
April 1976
Various CNS-active cannabinoids in which the alicyclic ring was thiopheno, cyclopenteno, or cyclohexeno with the alkyl substituent in various positions (structural types 1-6) were synthesized by procedures described previously. These compounds were compared in selected pharmacological tests in mice, rats, dogs, and cats. The results suggested that methyl substitution in the close proximity of the phenolic hydroxyl group strongly influenced the activity of some cannabinoids, particularly of those which had a planar five-membered alicyclic ring rather than a six-membered ring.
Duke Scholars
Published In
Journal of Medicinal Chemistry
DOI
EISSN
1520-4804
ISSN
0022-2623
Publication Date
April 1976
Volume
19
Issue
4
Start / End Page
552 / 554
Related Subject Headings
- Thiophenes
- Structure-Activity Relationship
- Seizures
- Reaction Time
- Rats
- Phytotherapy
- Motor Activity
- Mice
- Medicinal & Biomolecular Chemistry
- Hypnotics and Sedatives
Citation
APA
Chicago
ICMJE
MLA
NLM
Razdan, R. K., Handrick, G. R., Dalzell, H. C., Howes, J. F., Winn, M., Plotnikoff, N. P., … Dren, A. T. (1976). Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs. Journal of Medicinal Chemistry, 19(4), 552–554. https://doi.org/10.1021/jm00226a023
Razdan, R. K., G. R. Handrick, H. C. Dalzell, J. F. Howes, M. Winn, N. P. Plotnikoff, P. W. Dodge, and A. T. Dren. “Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs.” Journal of Medicinal Chemistry 19, no. 4 (April 1976): 552–54. https://doi.org/10.1021/jm00226a023.
Razdan RK, Handrick GR, Dalzell HC, Howes JF, Winn M, Plotnikoff NP, et al. Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs. Journal of Medicinal Chemistry. 1976 Apr;19(4):552–4.
Razdan, R. K., et al. “Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs.” Journal of Medicinal Chemistry, vol. 19, no. 4, Apr. 1976, pp. 552–54. Epmc, doi:10.1021/jm00226a023.
Razdan RK, Handrick GR, Dalzell HC, Howes JF, Winn M, Plotnikoff NP, Dodge PW, Dren AT. Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs. Journal of Medicinal Chemistry. 1976 Apr;19(4):552–554.

Published In
Journal of Medicinal Chemistry
DOI
EISSN
1520-4804
ISSN
0022-2623
Publication Date
April 1976
Volume
19
Issue
4
Start / End Page
552 / 554
Related Subject Headings
- Thiophenes
- Structure-Activity Relationship
- Seizures
- Reaction Time
- Rats
- Phytotherapy
- Motor Activity
- Mice
- Medicinal & Biomolecular Chemistry
- Hypnotics and Sedatives