Skip to main content
Journal cover image

Impact of childhood trauma on treatment outcome in the Treatment for Adolescents with Depression Study (TADS).

Publication ,  Journal Article
Lewis, CC; Simons, AD; Nguyen, LJ; Murakami, JL; Reid, MW; Silva, SG; March, JS
Published in: Journal of the American Academy of Child and Adolescent Psychiatry
February 2010

The impact of childhood trauma was examined in 427 adolescents (54% girls, 74% Caucasian, mean = 14.6, SD = 1.5) with major depressive disorder participating in the Treatment for Adolescents with Depression Study (TADS).TADS compared the efficacy of cognitive behavioral therapy (CBT), fluoxetine (FLX), their combination (COMB), and placebo (PBO). Teens were separated into four trauma history groups: (1) no trauma; (2) trauma, no abuse; (3) physical abuse; (4), and sexual abuse. The effects of treatment and trauma history on depression severity across 12 weeks of acute treatment, as measured by the Children's Depression Rating Scale-Revised (CDRS-R), were examined.A significant trauma-by-treatment-by-time interaction indicated that trauma history moderated treatment. The Week 12 primary efficacy findings previously reported by TADS were replicated in the no trauma group (n = 201): COMB = FLX > CBT = PBO. No significant differences in treatment arms were observed among the trauma, no abuse, or physical abuse group. Teens with a history of sexual abuse treated with COMB, FLX, and PBO showed significant and equivalent improvement on the CDRS-R (mean <45), whereas the mean CDRS-R for the CBT group tended to remain in the depressed range (mean >45). Baseline suicidality and self-reported depression were significantly related to a history of sexual abuse.The study was limited by the level of detail regarding childhood traumatic experiences. Results are discussed in terms of the implications for treating depressed adolescents with traumatic backgrounds.Clinical Trials Registry Information: Treatment for Adolescents with Depression Study; http://www.clinicaltrials.gov, NCT00006286.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Journal of the American Academy of Child and Adolescent Psychiatry

DOI

EISSN

1527-5418

ISSN

0890-8567

Publication Date

February 2010

Volume

49

Issue

2

Start / End Page

132 / 140

Related Subject Headings

  • Treatment Outcome
  • Stress Disorders, Post-Traumatic
  • Psychometrics
  • Personality Inventory
  • Male
  • Longitudinal Studies
  • Life Change Events
  • Humans
  • Fluoxetine
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lewis, C. C., Simons, A. D., Nguyen, L. J., Murakami, J. L., Reid, M. W., Silva, S. G., & March, J. S. (2010). Impact of childhood trauma on treatment outcome in the Treatment for Adolescents with Depression Study (TADS). Journal of the American Academy of Child and Adolescent Psychiatry, 49(2), 132–140. https://doi.org/10.1097/00004583-201002000-00007
Lewis, Cara C., Anne D. Simons, Lananh J. Nguyen, Jessica L. Murakami, Mark W. Reid, Susan G. Silva, and John S. March. “Impact of childhood trauma on treatment outcome in the Treatment for Adolescents with Depression Study (TADS).Journal of the American Academy of Child and Adolescent Psychiatry 49, no. 2 (February 2010): 132–40. https://doi.org/10.1097/00004583-201002000-00007.
Lewis CC, Simons AD, Nguyen LJ, Murakami JL, Reid MW, Silva SG, et al. Impact of childhood trauma on treatment outcome in the Treatment for Adolescents with Depression Study (TADS). Journal of the American Academy of Child and Adolescent Psychiatry. 2010 Feb;49(2):132–40.
Lewis, Cara C., et al. “Impact of childhood trauma on treatment outcome in the Treatment for Adolescents with Depression Study (TADS).Journal of the American Academy of Child and Adolescent Psychiatry, vol. 49, no. 2, Feb. 2010, pp. 132–40. Epmc, doi:10.1097/00004583-201002000-00007.
Lewis CC, Simons AD, Nguyen LJ, Murakami JL, Reid MW, Silva SG, March JS. Impact of childhood trauma on treatment outcome in the Treatment for Adolescents with Depression Study (TADS). Journal of the American Academy of Child and Adolescent Psychiatry. 2010 Feb;49(2):132–140.
Journal cover image

Published In

Journal of the American Academy of Child and Adolescent Psychiatry

DOI

EISSN

1527-5418

ISSN

0890-8567

Publication Date

February 2010

Volume

49

Issue

2

Start / End Page

132 / 140

Related Subject Headings

  • Treatment Outcome
  • Stress Disorders, Post-Traumatic
  • Psychometrics
  • Personality Inventory
  • Male
  • Longitudinal Studies
  • Life Change Events
  • Humans
  • Fluoxetine
  • Female