The molecular biology of Sertoli-Leydig cell tumors of the ovary

Sertoli-Leydig tumors are infrequent neoplasms of the ovary that often have androgenic and estrogenic clinical effects. Production of these hormones occurs within both the Sertoli and Leydig cells and can be influenced by other steroid and peptide hormones. Several antigens, including EMA, Melan-A, and inhibin, may be useful in distinguishing Sertoli-Leydig tumors from other malignancies. Karyotypic abnormalities, including X chromosome mosaicism, occur in some cases, but it is difficult to estimate their frequency or significance due to the rarity of these tumors. Few studies have examined the role of specific oncogenes or tumor suppressor genes in Sertoli-Leydig tumors, however, mutations in a G protein oncogene (Gi) have been noted in some cases. Further studies are needed to elucidate the molecular alterations that underlie the development of these tumors.

Duke Scholars

Author Andrew Berchuck Obstetrics and Gynecology, Gynecologic Oncology