Scholars@Duke

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.

Publication ,  Journal Article
Okada, Y; Sim, X; Go, MJ; Wu, J-Y; Gu, D; Takeuchi, F; Takahashi, A; Maeda, S; Tsunoda, T; Chen, P; Lim, S-C; Wong, T-Y; Liu, J; Young, TL ...
Published in: Nat Genet
July 15, 2012
Published version (DOI) Link to item

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

Duke Scholars

Yongmei Liu
Author Yongmei Liu Medicine, Cardiology
Tien Yin Wong
Author Tien Yin Wong Ophthalmology
Terri Lois Young
Author Terri Lois Young Ophthalmology
Yuan-Tsong Chen
Author Yuan-Tsong Chen Pediatrics, Medical Genetics
Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Genet

DOI

10.1038/ng.2352

EISSN

1546-1718

Publication Date

July 15, 2012

Volume

44

Issue

8

Start / End Page

904 / 909

Location

United States

Related Subject Headings

  • Uric Acid
  • Renal Insufficiency, Chronic
  • Polymorphism, Single Nucleotide
  • Kidney
  • Humans
  • Glomerular Filtration Rate
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Developmental Biology
  • Creatinine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Okada, Y., Sim, X., Go, M. J., Wu, J.-Y., Gu, D., Takeuchi, F., … Tanaka, T. (2012). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nat Genet, 44(8), 904–909. https://doi.org/10.1038/ng.2352
Okada, Yukinori, Xueling Sim, Min Jin Go, Jer-Yuarn Wu, Dongfeng Gu, Fumihiko Takeuchi, Atsushi Takahashi, et al. “Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.” Nat Genet 44, no. 8 (July 15, 2012): 904–9. https://doi.org/10.1038/ng.2352.
Okada Y, Sim X, Go MJ, Wu J-Y, Gu D, Takeuchi F, et al. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nat Genet. 2012 Jul 15;44(8):904–9.
Okada, Yukinori, et al. “Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.” Nat Genet, vol. 44, no. 8, July 2012, pp. 904–09. Pubmed, doi:10.1038/ng.2352.
Okada Y, Sim X, Go MJ, Wu J-Y, Gu D, Takeuchi F, Takahashi A, Maeda S, Tsunoda T, Chen P, Lim S-C, Wong T-Y, Liu J, Young TL, Aung T, Seielstad M, Teo Y-Y, Kim YJ, Lee J-Y, Han B-G, Kang D, Chen C-H, Tsai F-J, Chang L-C, Fann S-JC, Mei H, Rao DC, Hixson JE, Chen S, Katsuya T, Isono M, Ogihara T, Chambers JC, Zhang W, Kooner JS, KidneyGen Consortium, CKDGen Consortium, Albrecht E, GUGC consortium, Yamamoto K, Kubo M, Nakamura Y, Kamatani N, Kato N, He J, Chen Y-T, Cho YS, Tai E-S, Tanaka T. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nat Genet. 2012 Jul 15;44(8):904–909.

Published In

Nat Genet

DOI

10.1038/ng.2352

EISSN

1546-1718

Publication Date

July 15, 2012

Volume

44

Issue

8

Start / End Page

904 / 909

Location

United States

Related Subject Headings

  • Uric Acid
  • Renal Insufficiency, Chronic
  • Polymorphism, Single Nucleotide
  • Kidney
  • Humans
  • Glomerular Filtration Rate
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Developmental Biology
  • Creatinine