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Elastin-like polypeptide-doxorubicin conjugates for cancer therapy

Publication ,  Journal Article
Dreher, M; Raucher, D; Balu, N; Colvin, M; Ludeman, S; Chilkoti, A
Published in: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
December 1, 2002

Thermally responsive elastin-like polypeptides (ELP) were synthesized by recombinant DNA techniques and conjugated to doxorubicin through an acid labile bond. The thermal properties, release of doxorubicin, uptake of ELP, cytotoxicity and cellular localization of ELP-doxorubicin conjugates were investigated in this study.

Duke Scholars

Published In

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

ISSN

0589-1019

Publication Date

December 1, 2002

Volume

1

Start / End Page

524 / 525
 

Citation

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Dreher, M., Raucher, D., Balu, N., Colvin, M., Ludeman, S., & Chilkoti, A. (2002). Elastin-like polypeptide-doxorubicin conjugates for cancer therapy. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 1, 524–525.
Dreher, M., D. Raucher, N. Balu, M. Colvin, S. Ludeman, and A. Chilkoti. “Elastin-like polypeptide-doxorubicin conjugates for cancer therapy.” Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 1 (December 1, 2002): 524–25.
Dreher M, Raucher D, Balu N, Colvin M, Ludeman S, Chilkoti A. Elastin-like polypeptide-doxorubicin conjugates for cancer therapy. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2002 Dec 1;1:524–5.
Dreher, M., et al. “Elastin-like polypeptide-doxorubicin conjugates for cancer therapy.” Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 1, Dec. 2002, pp. 524–25.
Dreher M, Raucher D, Balu N, Colvin M, Ludeman S, Chilkoti A. Elastin-like polypeptide-doxorubicin conjugates for cancer therapy. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2002 Dec 1;1:524–525.

Published In

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

ISSN

0589-1019

Publication Date

December 1, 2002

Volume

1

Start / End Page

524 / 525