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Metformin reverses fatty liver disease in obese, leptin-deficient mice.

Publication ,  Journal Article
Lin, HZ; Yang, SQ; Chuckaree, C; Kuhajda, F; Ronnet, G; Diehl, AM
Published in: Nat Med
September 2000

There is no known treatment for fatty liver, a ubiquitous cause of chronic liver disease. However, because it is associated with hyperinsulinemia and insulin-resistance, insulin-sensitizing agents might be beneficial. To evaluate this possibility, insulin-resistant ob/ob mice with fatty livers were treated with metformin, an agent that improves hepatic insulin-resistance. Metformin improved fatty liver disease, reversing hepatomegaly, steatosis and aminotransferase abnormalities. The therapeutic mechanism likely involves inhibited hepatic expression of tumor necrosis factor (TNF) alpha and TNF-inducible factors that promote hepatic lipid accumulation and ATP depletion. These findings suggest a mechanism of action for metformin and identify novel therapeutic targets in insulin-resistant states.

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Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

September 2000

Volume

6

Issue

9

Start / End Page

998 / 1003

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Transaminases
  • Obesity
  • Mice, Obese
  • Mice
  • Metformin
  • Lipids
  • Insulin Resistance
  • Immunology
  • Hypoglycemic Agents
 

Citation

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MLA
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Lin, H. Z., Yang, S. Q., Chuckaree, C., Kuhajda, F., Ronnet, G., & Diehl, A. M. (2000). Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat Med, 6(9), 998–1003. https://doi.org/10.1038/79697
Lin, H. Z., S. Q. Yang, C. Chuckaree, F. Kuhajda, G. Ronnet, and A. M. Diehl. “Metformin reverses fatty liver disease in obese, leptin-deficient mice.Nat Med 6, no. 9 (September 2000): 998–1003. https://doi.org/10.1038/79697.
Lin HZ, Yang SQ, Chuckaree C, Kuhajda F, Ronnet G, Diehl AM. Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat Med. 2000 Sep;6(9):998–1003.
Lin, H. Z., et al. “Metformin reverses fatty liver disease in obese, leptin-deficient mice.Nat Med, vol. 6, no. 9, Sept. 2000, pp. 998–1003. Pubmed, doi:10.1038/79697.
Lin HZ, Yang SQ, Chuckaree C, Kuhajda F, Ronnet G, Diehl AM. Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat Med. 2000 Sep;6(9):998–1003.

Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

September 2000

Volume

6

Issue

9

Start / End Page

998 / 1003

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Transaminases
  • Obesity
  • Mice, Obese
  • Mice
  • Metformin
  • Lipids
  • Insulin Resistance
  • Immunology
  • Hypoglycemic Agents