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The role of cytokines in hepatic regeneration

Publication ,  Journal Article
Diehl, AM
Published in: Current Opinion in Gastroenterology
January 1, 1997

Regulation of the regenerative response to liver injury is a complex process. Recent work from several groups demonstrates that cytokines, including tumor necrosis factor-α and tumor necrosis factor-regulated cytokines, such as interleukin-6, play a critical role in initiating hepatocyte proliferation during liver regeneration. These cytokines appear to promote hepatocyte proliferation by activating transcription factors that are necessary during prereplicative stages of the cell cycle. They may also influence the production of mitogenic factors by liver nonparenchymal cells. Emerging evidence indicates that other cytokines, including interleukin-10 and transforming growth factor-β, are also induced during liver regeneration and act to limit the biologic activity of tumor necrosis factor. Thus, liver injury triggers a cytokine cascade that regulates the subsequent regenerative response.

Duke Scholars

Published In

Current Opinion in Gastroenterology

DOI

ISSN

0267-1379

Publication Date

January 1, 1997

Volume

13

Issue

6

Start / End Page

525 / 533

Related Subject Headings

  • Gastroenterology & Hepatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Diehl, A. M. (1997). The role of cytokines in hepatic regeneration. Current Opinion in Gastroenterology, 13(6), 525–533. https://doi.org/10.1097/00001574-199711000-00014
Diehl, A. M. “The role of cytokines in hepatic regeneration.” Current Opinion in Gastroenterology 13, no. 6 (January 1, 1997): 525–33. https://doi.org/10.1097/00001574-199711000-00014.
Diehl AM. The role of cytokines in hepatic regeneration. Current Opinion in Gastroenterology. 1997 Jan 1;13(6):525–33.
Diehl, A. M. “The role of cytokines in hepatic regeneration.” Current Opinion in Gastroenterology, vol. 13, no. 6, Jan. 1997, pp. 525–33. Scopus, doi:10.1097/00001574-199711000-00014.
Diehl AM. The role of cytokines in hepatic regeneration. Current Opinion in Gastroenterology. 1997 Jan 1;13(6):525–533.

Published In

Current Opinion in Gastroenterology

DOI

ISSN

0267-1379

Publication Date

January 1, 1997

Volume

13

Issue

6

Start / End Page

525 / 533

Related Subject Headings

  • Gastroenterology & Hepatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences