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Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury.

Publication ,  Journal Article
Diehl, AM; Yin, M; Fleckenstein, J; Yang, SQ; Lin, HZ; Brenner, DA; Westwick, J; Bagby, G; Nelson, S
Published in: Am J Physiol
October 1994

After liver injury, remaining hepatocytes proliferate to regenerate the liver. Although the precise mechanisms that initiate and localize regeneration are unknown, local induction of c-jun is a critical, early step in the response. Treatment of rats with antibodies to tumor necrosis factor-alpha (TNF-alpha), a mediator of liver injury, inhibits regenerative induction of jun nuclear kinase activity and nuclear c-jun expression and alters the DNA binding activity of the c-jun transcription factor, AP-1, in liver. Pretreatment with anti-TNF antibodies does not affect pulmonary or renal c-jun expression or AP-1 binding activity post-partial hepatectomy. In primary hepatocyte cultures, TNF-alpha directly promotes the proliferative actions of mitogens, supporting in vivo evidence that it sensitizes hepatocytes to mitogens. Thus local release of TNF may act in a paracrine fashion to initiate regeneration in the injured liver by promoting induction of critical growth-related genes, such as c-jun.

Duke Scholars

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

October 1994

Volume

267

Issue

4 Pt 1

Start / End Page

G552 / G561

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Transcription Factor AP-1
  • Recombinant Proteins
  • Rats, Sprague-Dawley
  • Rats
  • RNA, Messenger
  • Proto-Oncogene Proteins c-jun
  • Oligonucleotide Probes
  • Molecular Sequence Data
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Diehl, A. M., Yin, M., Fleckenstein, J., Yang, S. Q., Lin, H. Z., Brenner, D. A., … Nelson, S. (1994). Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. Am J Physiol, 267(4 Pt 1), G552–G561. https://doi.org/10.1152/ajpgi.1994.267.4.G552
Diehl, A. M., M. Yin, J. Fleckenstein, S. Q. Yang, H. Z. Lin, D. A. Brenner, J. Westwick, G. Bagby, and S. Nelson. “Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury.Am J Physiol 267, no. 4 Pt 1 (October 1994): G552–61. https://doi.org/10.1152/ajpgi.1994.267.4.G552.
Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ, Brenner DA, et al. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. Am J Physiol. 1994 Oct;267(4 Pt 1):G552–61.
Diehl, A. M., et al. “Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury.Am J Physiol, vol. 267, no. 4 Pt 1, Oct. 1994, pp. G552–61. Pubmed, doi:10.1152/ajpgi.1994.267.4.G552.
Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ, Brenner DA, Westwick J, Bagby G, Nelson S. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. Am J Physiol. 1994 Oct;267(4 Pt 1):G552–G561.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

October 1994

Volume

267

Issue

4 Pt 1

Start / End Page

G552 / G561

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Transcription Factor AP-1
  • Recombinant Proteins
  • Rats, Sprague-Dawley
  • Rats
  • RNA, Messenger
  • Proto-Oncogene Proteins c-jun
  • Oligonucleotide Probes
  • Molecular Sequence Data
  • Male