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Cytokines and alcoholic liver disease.

Publication ,  Journal Article
McClain, C; Hill, D; Schmidt, J; Diehl, AM
Published in: Semin Liver Dis
May 1993

It is clear that cytokines cause metabolic disturbances that are similar to known complications of AH. TNF appears to be a proximal mediator of multiple types of experimental liver injury and TNF activity is elevated in ALD, as are the levels of certain other cytokines. On the other hand, low physiologic amounts of cytokines appear to be important for liver regeneration (and perhaps are beneficial to the organism as a whole). Goals for evaluation of anticytokine therapy in ALD will be: (1) determining the timing and type of the particular anticytokine employed (such as, immediate administration of antibody followed by an inhibitor of cytokine production), (2) appropriate monitoring of drug effects on cytokine metabolism as well as liver function and outcome, and (3) maintenance of the regenerative or positive physiologic effects of cytokines while blocking the cytolytic effects. Thus, we predict that ultimate anticytokine therapy will be directed at conserving the positive growth-enhancing effects of cytokines while attenuating their cytolytic effects.

Duke Scholars

Published In

Semin Liver Dis

DOI

ISSN

0272-8087

Publication Date

May 1993

Volume

13

Issue

2

Start / End Page

170 / 182

Location

United States

Related Subject Headings

  • Liver Regeneration
  • Liver Diseases, Alcoholic
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Cytokines
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
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ICMJE
MLA
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McClain, C., Hill, D., Schmidt, J., & Diehl, A. M. (1993). Cytokines and alcoholic liver disease. Semin Liver Dis, 13(2), 170–182. https://doi.org/10.1055/s-2007-1007347
McClain, C., D. Hill, J. Schmidt, and A. M. Diehl. “Cytokines and alcoholic liver disease.Semin Liver Dis 13, no. 2 (May 1993): 170–82. https://doi.org/10.1055/s-2007-1007347.
McClain C, Hill D, Schmidt J, Diehl AM. Cytokines and alcoholic liver disease. Semin Liver Dis. 1993 May;13(2):170–82.
McClain, C., et al. “Cytokines and alcoholic liver disease.Semin Liver Dis, vol. 13, no. 2, May 1993, pp. 170–82. Pubmed, doi:10.1055/s-2007-1007347.
McClain C, Hill D, Schmidt J, Diehl AM. Cytokines and alcoholic liver disease. Semin Liver Dis. 1993 May;13(2):170–182.
Journal cover image

Published In

Semin Liver Dis

DOI

ISSN

0272-8087

Publication Date

May 1993

Volume

13

Issue

2

Start / End Page

170 / 182

Location

United States

Related Subject Headings

  • Liver Regeneration
  • Liver Diseases, Alcoholic
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Cytokines
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences