Skip to main content
Journal cover image

The effect of chronic ethanol feeding on ornithine decarboxylase activity and liver regeneration.

Publication ,  Journal Article
Diehl, AM; Chacon, M; Wagner, P
Published in: Hepatology
1988

The effects of ethanol on liver regeneration are poorly understood. Acute and chronic exposure to ethanol have been found to exert opposite effects on the induction of ornithine decarboxylase, the rate-limiting enzyme for polyamine biosynthesis. Polyamines are necessary for DNA synthesis and liver regeneration after chemical or surgical liver injury. Short-term exposure to ethanol, which inhibits ornithine decarboxylase has been shown to inhibit DNA synthesis and liver regeneration, whereas more chronic exposure to ethanol increases ornithine decarboxylase activity and therefore could conceivably stimulate DNA synthesis and regeneration. To explore this later possibility, the effects of chronic ethanol consumption on ornithine decarboxylase activity, DNA synthesis and liver regeneration were studied in rats after sham laparotomy and partial hepatectomy. Chronic ethanol feeding failed to inhibit the induction of ornithine decarboxylase that occurred after partial hepatectomy and yet significantly inhibited posthepatectomy DNA synthesis and restitution of liver mass. These data suggest that the induction of hepatic polyamine biosynthesis is dissociated from DNA synthesis and liver regeneration after chronic consumption of ethanol.

Duke Scholars

Published In

Hepatology

DOI

ISSN

0270-9139

Publication Date

1988

Volume

8

Issue

2

Start / End Page

237 / 242

Location

United States

Related Subject Headings

  • Time Factors
  • Thymidine
  • Ornithine Decarboxylase
  • Mitosis
  • Liver Regeneration
  • Liver
  • Gastroenterology & Hepatology
  • Animals
  • Alcohol Drinking
  • 3204 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Diehl, A. M., Chacon, M., & Wagner, P. (1988). The effect of chronic ethanol feeding on ornithine decarboxylase activity and liver regeneration. Hepatology, 8(2), 237–242. https://doi.org/10.1002/hep.1840080208
Diehl, A. M., M. Chacon, and P. Wagner. “The effect of chronic ethanol feeding on ornithine decarboxylase activity and liver regeneration.Hepatology 8, no. 2 (1988): 237–42. https://doi.org/10.1002/hep.1840080208.
Diehl, A. M., et al. “The effect of chronic ethanol feeding on ornithine decarboxylase activity and liver regeneration.Hepatology, vol. 8, no. 2, 1988, pp. 237–42. Pubmed, doi:10.1002/hep.1840080208.
Journal cover image

Published In

Hepatology

DOI

ISSN

0270-9139

Publication Date

1988

Volume

8

Issue

2

Start / End Page

237 / 242

Location

United States

Related Subject Headings

  • Time Factors
  • Thymidine
  • Ornithine Decarboxylase
  • Mitosis
  • Liver Regeneration
  • Liver
  • Gastroenterology & Hepatology
  • Animals
  • Alcohol Drinking
  • 3204 Immunology