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Relationship between pyridoxal 5'-phosphate deficiency and aminotransferase levels in alcoholic hepatitis.

Publication ,  Journal Article
Diehl, AM; Potter, J; Boitnott, J; Van Duyn, MA; Herlong, HF; Mezey, E
Published in: Gastroenterology
April 1984

The relationship between pyridoxal phosphate deficiency and activities of serum and liver aminotransferases was studied in 12 patients with alcoholic hepatitis. Plasma pyridoxal phosphate and the activities of liver aminotransferases were initially decreased in the patients, as compared with mean values in controls with normal hepatic histology. Addition of pyridoxal phosphate to liver homogenates increased liver alanine aminotransferase, but not aspartate aminotransferase, in all patients with initially low plasma pyridoxal phosphate. After 1 mo of abstinence from alcohol, with intake of an adequate diet and pyridoxine supplementation, plasma pyridoxal phosphate increased in all patients with initially low values (p less than 0.02). Serum aspartate aminotransferase decreased, whereas serum alanine aminotransferase increased, resulting in a decrease in their ratio in serum (p less than 0.001). Liver alanine aminotransferase increased (p less than 0.005), whereas liver aspartate aminotransferase remained unchanged. These data suggest that pyridoxal 5'-phosphate depletion is partially responsible for the low serum alanine to aspartate aminotransferase ratio that is typical of patients with alcoholic hepatitis.

Duke Scholars

Published In

Gastroenterology

ISSN

0016-5085

Publication Date

April 1984

Volume

86

Issue

4

Start / End Page

632 / 636

Location

United States

Related Subject Headings

  • Pyridoxine
  • Pyridoxal Phosphate
  • Nutritional Physiological Phenomena
  • Male
  • Liver
  • Humans
  • Hepatitis, Alcoholic
  • Gastroenterology & Hepatology
  • Female
  • Aspartate Aminotransferases
 

Citation

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Diehl, A. M., Potter, J., Boitnott, J., Van Duyn, M. A., Herlong, H. F., & Mezey, E. (1984). Relationship between pyridoxal 5'-phosphate deficiency and aminotransferase levels in alcoholic hepatitis. Gastroenterology, 86(4), 632–636.
Diehl, A. M., J. Potter, J. Boitnott, M. A. Van Duyn, H. F. Herlong, and E. Mezey. “Relationship between pyridoxal 5'-phosphate deficiency and aminotransferase levels in alcoholic hepatitis.Gastroenterology 86, no. 4 (April 1984): 632–36.
Diehl AM, Potter J, Boitnott J, Van Duyn MA, Herlong HF, Mezey E. Relationship between pyridoxal 5'-phosphate deficiency and aminotransferase levels in alcoholic hepatitis. Gastroenterology. 1984 Apr;86(4):632–6.
Diehl, A. M., et al. “Relationship between pyridoxal 5'-phosphate deficiency and aminotransferase levels in alcoholic hepatitis.Gastroenterology, vol. 86, no. 4, Apr. 1984, pp. 632–36.
Diehl AM, Potter J, Boitnott J, Van Duyn MA, Herlong HF, Mezey E. Relationship between pyridoxal 5'-phosphate deficiency and aminotransferase levels in alcoholic hepatitis. Gastroenterology. 1984 Apr;86(4):632–636.
Journal cover image

Published In

Gastroenterology

ISSN

0016-5085

Publication Date

April 1984

Volume

86

Issue

4

Start / End Page

632 / 636

Location

United States

Related Subject Headings

  • Pyridoxine
  • Pyridoxal Phosphate
  • Nutritional Physiological Phenomena
  • Male
  • Liver
  • Humans
  • Hepatitis, Alcoholic
  • Gastroenterology & Hepatology
  • Female
  • Aspartate Aminotransferases