Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome.
Angiotensin II is a potent regulator of cardiovascular homeostasis and binds to two different G-protein-coupled receptors. While the type 1 receptor (AT1) mediates the cardiovascular actions of angiotensin II, the function of the recently cloned type 2 receptor (AT2) remains unknown. We have cloned the mouse AT2 receptor gene (Agtr2) and determined its map position by linkage analysis using an interspecific backcross (C57BL/6J x Mus spretus).Agtr2 is located on the proximal mouse X chromosome between DXMit85 and DXMit49, in a region of conserved synteny with a part of the human X chromosome implicated in inherited forms of premature ovarian failure. The mapping of Agtr2 may expand a region of conserved synteny with human Xq26 that includes Hprt.
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- X Chromosome
- Receptors, Angiotensin
- Primary Ovarian Insufficiency
- Molecular Sequence Data
- Mice, Inbred C57BL
- Mice
- Humans
- Genetics & Heredity
- Genetic Linkage
- Female
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- X Chromosome
- Receptors, Angiotensin
- Primary Ovarian Insufficiency
- Molecular Sequence Data
- Mice, Inbred C57BL
- Mice
- Humans
- Genetics & Heredity
- Genetic Linkage
- Female