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Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung.

Publication ,  Journal Article
Koike, G; Horiuchi, M; Yamada, T; Szpirer, C; Jacob, HJ; Dzau, VJ
Published in: Biochem Biophys Res Commun
September 30, 1994

The human type 2 angiotensin II receptor (AT2R) gene was isolated from a human genomic DNA library of adult female leukocytes. The putative coding region of the human AT2R gene is intronless. The primary structure of the human AT2R deduced from the nucleotide sequence of this putative coding region contains 363 amino acid residues and is highly homologous to the sequences of the rat and mouse AT2R. The human AT2R gene was mapped to the X chromosome using chromosomal assignment analysis with a human/rodent somatic cell hybrid panel. Northern blot analysis demonstrated a 3.0 kb mRNA in the human fetal lung and kidney and the human adult lung. These data and probes should enhance research in human AT2R biology.

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Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

September 30, 1994

Volume

203

Issue

3

Start / End Page

1842 / 1850

Location

United States

Related Subject Headings

  • X Chromosome
  • Transfection
  • Sequence Homology, Amino Acid
  • Receptors, Angiotensin
  • Rats
  • RNA, Messenger
  • Polymerase Chain Reaction
  • Molecular Sequence Data
  • Mice
  • Lung
 

Citation

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Koike, G., Horiuchi, M., Yamada, T., Szpirer, C., Jacob, H. J., & Dzau, V. J. (1994). Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. Biochem Biophys Res Commun, 203(3), 1842–1850. https://doi.org/10.1006/bbrc.1994.2402
Koike, G., M. Horiuchi, T. Yamada, C. Szpirer, H. J. Jacob, and V. J. Dzau. “Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung.Biochem Biophys Res Commun 203, no. 3 (September 30, 1994): 1842–50. https://doi.org/10.1006/bbrc.1994.2402.
Koike G, Horiuchi M, Yamada T, Szpirer C, Jacob HJ, Dzau VJ. Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. Biochem Biophys Res Commun. 1994 Sep 30;203(3):1842–50.
Koike, G., et al. “Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung.Biochem Biophys Res Commun, vol. 203, no. 3, Sept. 1994, pp. 1842–50. Pubmed, doi:10.1006/bbrc.1994.2402.
Koike G, Horiuchi M, Yamada T, Szpirer C, Jacob HJ, Dzau VJ. Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. Biochem Biophys Res Commun. 1994 Sep 30;203(3):1842–1850.
Journal cover image

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

September 30, 1994

Volume

203

Issue

3

Start / End Page

1842 / 1850

Location

United States

Related Subject Headings

  • X Chromosome
  • Transfection
  • Sequence Homology, Amino Acid
  • Receptors, Angiotensin
  • Rats
  • RNA, Messenger
  • Polymerase Chain Reaction
  • Molecular Sequence Data
  • Mice
  • Lung