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Induction of angiotensin converting enzyme in the neointima after vascular injury. Possible role in restenosis.

Publication ,  Journal Article
Rakugi, H; Kim, DK; Krieger, JE; Wang, DS; Dzau, VJ; Pratt, RE
Published in: J Clin Invest
January 1994

Angiotensin II (Ang II) promotes growth of vascular smooth muscle cells in vitro. Consistent with this, Ang II enhances neointimal proliferation in vivo after vascular injury, while angiotensin converting enzyme (ACE) inhibitors attenuate this process. Since tissue ACE plays a key role in the control of local Ang II production, we examined whether vascular injury resulted in an increase in vascular ACE expression that may result in increased Ang II production. Abdominal aorta of Sprague-Dawley rats were injured with a 2 French balloon catheter. Morphometrical changes, ACE enzymatic activity, and localization of ACE by immunohistochemistry in injured and uninjured aorta were analyzed. Vascular ACE activity in the injured aorta was significantly higher than in the uninjured aorta, while serum and lung ACE levels were not different between the two groups. The cellular distribution of the ACE protein in the neointima was similar to that of alpha smooth muscle actin but differed from those of endothelial (von Willebrand factor) or monocytes/macrophages (ED-1) markers, demonstrating that ACE was expressed in neointimal smooth muscle cells. These data demonstrate that vascular injury results in the induction of vascular ACE and suggest that the inhibition of vascular ACE may be important in the prevention of restenosis after balloon injury.

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Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

January 1994

Volume

93

Issue

1

Start / End Page

339 / 346

Location

United States

Related Subject Headings

  • Tetrahydroisoquinolines
  • Rats, Sprague-Dawley
  • Rats
  • Quinapril
  • Peptidyl-Dipeptidase A
  • Muscle, Smooth, Vascular
  • Male
  • Isoquinolines
  • Immunology
  • Enzyme Induction
 

Citation

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Rakugi, H., Kim, D. K., Krieger, J. E., Wang, D. S., Dzau, V. J., & Pratt, R. E. (1994). Induction of angiotensin converting enzyme in the neointima after vascular injury. Possible role in restenosis. J Clin Invest, 93(1), 339–346. https://doi.org/10.1172/JCI116965
Rakugi, H., D. K. Kim, J. E. Krieger, D. S. Wang, V. J. Dzau, and R. E. Pratt. “Induction of angiotensin converting enzyme in the neointima after vascular injury. Possible role in restenosis.J Clin Invest 93, no. 1 (January 1994): 339–46. https://doi.org/10.1172/JCI116965.
Rakugi H, Kim DK, Krieger JE, Wang DS, Dzau VJ, Pratt RE. Induction of angiotensin converting enzyme in the neointima after vascular injury. Possible role in restenosis. J Clin Invest. 1994 Jan;93(1):339–46.
Rakugi, H., et al. “Induction of angiotensin converting enzyme in the neointima after vascular injury. Possible role in restenosis.J Clin Invest, vol. 93, no. 1, Jan. 1994, pp. 339–46. Pubmed, doi:10.1172/JCI116965.
Rakugi H, Kim DK, Krieger JE, Wang DS, Dzau VJ, Pratt RE. Induction of angiotensin converting enzyme in the neointima after vascular injury. Possible role in restenosis. J Clin Invest. 1994 Jan;93(1):339–346.

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

January 1994

Volume

93

Issue

1

Start / End Page

339 / 346

Location

United States

Related Subject Headings

  • Tetrahydroisoquinolines
  • Rats, Sprague-Dawley
  • Rats
  • Quinapril
  • Peptidyl-Dipeptidase A
  • Muscle, Smooth, Vascular
  • Male
  • Isoquinolines
  • Immunology
  • Enzyme Induction