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Autocrine stimulation of mas oncogene leads to altered growth control.

Publication ,  Journal Article
Andrawis, NS; Dzau, VJ; Pratt, RE
Published in: Cell Biol Int Rep
June 1992

Mas oncogene has been shown to have focus-inducing ability in NIH 3T3 cells which are tumorigenic in vivo in nude mice. Its stable expression in a variety of cell lines conferred some angiotensin responsiveness. To understand why mas-transfected cells exhibit a transformed phenotype and if angiotensin responsiveness plays any role in this process, we studied the growth characteristics of mas-transfected 3T3 cells and demonstrated that they lose contact inhibition, exhibit foci formation, and increased DNA synthesis even in absence of serum. Our results suggest that the transformed phenotype is due to the production of a mas receptor ligand distinct from angiotensin.

Duke Scholars

Published In

Cell Biol Int Rep

DOI

ISSN

0309-1651

Publication Date

June 1992

Volume

16

Issue

6

Start / End Page

547 / 556

Location

England

Related Subject Headings

  • Recombinant Proteins
  • Receptors, G-Protein-Coupled
  • Proto-Oncogene Proteins
  • Proto-Oncogene Mas
  • Oncogenes
  • Neoplasm Proteins
  • Mice, Inbred BALB C
  • Mice
  • Enalaprilat
  • DNA Replication
 

Citation

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Andrawis, N. S., Dzau, V. J., & Pratt, R. E. (1992). Autocrine stimulation of mas oncogene leads to altered growth control. Cell Biol Int Rep, 16(6), 547–556. https://doi.org/10.1016/s0309-1651(05)80053-0
Andrawis, N. S., V. J. Dzau, and R. E. Pratt. “Autocrine stimulation of mas oncogene leads to altered growth control.Cell Biol Int Rep 16, no. 6 (June 1992): 547–56. https://doi.org/10.1016/s0309-1651(05)80053-0.
Andrawis NS, Dzau VJ, Pratt RE. Autocrine stimulation of mas oncogene leads to altered growth control. Cell Biol Int Rep. 1992 Jun;16(6):547–56.
Andrawis, N. S., et al. “Autocrine stimulation of mas oncogene leads to altered growth control.Cell Biol Int Rep, vol. 16, no. 6, June 1992, pp. 547–56. Pubmed, doi:10.1016/s0309-1651(05)80053-0.
Andrawis NS, Dzau VJ, Pratt RE. Autocrine stimulation of mas oncogene leads to altered growth control. Cell Biol Int Rep. 1992 Jun;16(6):547–556.

Published In

Cell Biol Int Rep

DOI

ISSN

0309-1651

Publication Date

June 1992

Volume

16

Issue

6

Start / End Page

547 / 556

Location

England

Related Subject Headings

  • Recombinant Proteins
  • Receptors, G-Protein-Coupled
  • Proto-Oncogene Proteins
  • Proto-Oncogene Mas
  • Oncogenes
  • Neoplasm Proteins
  • Mice, Inbred BALB C
  • Mice
  • Enalaprilat
  • DNA Replication