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Molecular mechanisms of vascular renin-angiotensin system in myointimal hyperplasia.

Publication ,  Journal Article
Dzau, VJ; Gibbons, GH; Pratt, RE
Published in: Hypertension
October 1991

Angiotensin II has been shown by many investigators to be a potent growth factor for vascular smooth cells in culture as well as in vivo. Depending on the conditions, the response of these cells is either hypertrophy or hyperplasia. These observations have important clinical implications, because it has been shown that angiotensin II participates in the hypertrophic response of the vessel wall during hypertension and the hyperplastic response after balloon angioplasty. Thus, an understanding of the molecular mechanism of these responses is important in the development of potential treatment strategies. This review examines the evidence for the growth-promoting properties of angiotensin II, concentrating on these molecular mechanisms. Hypotheses are presented that may explain the bifunctional effects (hypertrophy versus hyperplasia) of angiotensin II. These hypotheses revolve around the interaction of angiotensin with endothelium- and smooth muscle cell-derived products. These autocrine and paracrine interactions play important roles in the modulation of vascular structure.

Duke Scholars

Published In

Hypertension

DOI

ISSN

0194-911X

Publication Date

October 1991

Volume

18

Issue

4 Suppl

Start / End Page

II100 / II105

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Platelet-Derived Growth Factor
  • Muscle, Smooth, Vascular
  • Hyperplasia
  • Humans
  • Endothelium, Vascular
  • Cell Division
  • Cardiovascular System & Hematology
  • Animals
  • Angiotensinogen
 

Citation

APA
Chicago
ICMJE
MLA
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Dzau, V. J., Gibbons, G. H., & Pratt, R. E. (1991). Molecular mechanisms of vascular renin-angiotensin system in myointimal hyperplasia. Hypertension, 18(4 Suppl), II100–II105. https://doi.org/10.1161/01.hyp.18.4_suppl.ii100
Dzau, V. J., G. H. Gibbons, and R. E. Pratt. “Molecular mechanisms of vascular renin-angiotensin system in myointimal hyperplasia.Hypertension 18, no. 4 Suppl (October 1991): II100–105. https://doi.org/10.1161/01.hyp.18.4_suppl.ii100.
Dzau VJ, Gibbons GH, Pratt RE. Molecular mechanisms of vascular renin-angiotensin system in myointimal hyperplasia. Hypertension. 1991 Oct;18(4 Suppl):II100–5.
Dzau, V. J., et al. “Molecular mechanisms of vascular renin-angiotensin system in myointimal hyperplasia.Hypertension, vol. 18, no. 4 Suppl, Oct. 1991, pp. II100–05. Pubmed, doi:10.1161/01.hyp.18.4_suppl.ii100.
Dzau VJ, Gibbons GH, Pratt RE. Molecular mechanisms of vascular renin-angiotensin system in myointimal hyperplasia. Hypertension. 1991 Oct;18(4 Suppl):II100–II105.

Published In

Hypertension

DOI

ISSN

0194-911X

Publication Date

October 1991

Volume

18

Issue

4 Suppl

Start / End Page

II100 / II105

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Platelet-Derived Growth Factor
  • Muscle, Smooth, Vascular
  • Hyperplasia
  • Humans
  • Endothelium, Vascular
  • Cell Division
  • Cardiovascular System & Hematology
  • Animals
  • Angiotensinogen