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The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2.

Publication ,  Journal Article
Stubbs, L; Huxley, C; Hogan, B; Evans, T; Fried, M; Duboule, D; Lehrach, H
Published in: Genomics
April 1990

Using an interspecies backcross, we have mapped the HOX-5 and surfeit (surf) gene clusters within the proximal portion of mouse chromosome 2. While the HOX-5 cluster of homeobox-containing genes has been localized to chromosome 2, bands C3-E1, by in situ hybridization, its more precise position relative to the genes and cloned markers of chromosome 2 was not known. Surfeit, a tight cluster of at least six highly conserved "housekeeping" genes, has not been previously mapped in mouse, but has been localized to human chromosome 9q, a region of the human genome with strong homology to proximal mouse chromosome 2. The data presented here place HOX-5 in the vicinity of the closely linked set of developmental mutations rachiterata, lethargic, and fidget and place surf close to the proto-oncogene Abl, near the centromere of chromosome 2.

Duke Scholars

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

April 1990

Volume

6

Issue

4

Start / End Page

645 / 650

Location

United States

Related Subject Headings

  • Recombination, Genetic
  • Proto-Oncogenes
  • Proto-Oncogene Proteins c-abl
  • Proto-Oncogene Proteins
  • Proto-Oncogene Mas
  • Polymorphism, Restriction Fragment Length
  • Muridae
  • Mice, Inbred C57BL
  • Mice
  • Male
 

Citation

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ICMJE
MLA
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Stubbs, L., Huxley, C., Hogan, B., Evans, T., Fried, M., Duboule, D., & Lehrach, H. (1990). The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2. Genomics, 6(4), 645–650. https://doi.org/10.1016/0888-7543(90)90499-k
Stubbs, L., C. Huxley, B. Hogan, T. Evans, M. Fried, D. Duboule, and H. Lehrach. “The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2.Genomics 6, no. 4 (April 1990): 645–50. https://doi.org/10.1016/0888-7543(90)90499-k.
Stubbs L, Huxley C, Hogan B, Evans T, Fried M, Duboule D, et al. The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2. Genomics. 1990 Apr;6(4):645–50.
Stubbs, L., et al. “The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2.Genomics, vol. 6, no. 4, Apr. 1990, pp. 645–50. Pubmed, doi:10.1016/0888-7543(90)90499-k.
Stubbs L, Huxley C, Hogan B, Evans T, Fried M, Duboule D, Lehrach H. The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2. Genomics. 1990 Apr;6(4):645–650.
Journal cover image

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

April 1990

Volume

6

Issue

4

Start / End Page

645 / 650

Location

United States

Related Subject Headings

  • Recombination, Genetic
  • Proto-Oncogenes
  • Proto-Oncogene Proteins c-abl
  • Proto-Oncogene Proteins
  • Proto-Oncogene Mas
  • Polymorphism, Restriction Fragment Length
  • Muridae
  • Mice, Inbred C57BL
  • Mice
  • Male