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Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord.

Publication ,  Journal Article
Zhang, M; Ji, RR; Fang, Y; Han, JS
Published in: Zhongguo Yao Li Xue Bao
January 1994

Capsaicin (Cap) is a pharmacological tool to inactivate nociceptive afferents. The present study was undertaken to investigate the effects of topical application of Cap to sciatic nerve on the formalin-induced expression of proto-oncogene proteins c-fos in the rat spinal cord using immunohistochemical display of fos-like protein. In rats subjected to formalin injection into the hind paw, numerous fos-like immunoreactivity (FLI) neurons were found in the spinal dorsal horn, with heavy labeling in laminae I-II and V-VI. Following pretreatment of Cap, formalin-induced FLI expression was significantly abolished. It was suggested that activation of Cap-sensitive unmyelinated nociceptive afferents following formalin injection was primarily responsible for the activation of c-fos gene. Our data also provided further evidence supporting that topical application was an effective way to block the transmission of noxious primary afferents.

Duke Scholars

Published In

Zhongguo Yao Li Xue Bao

ISSN

0253-9756

Publication Date

January 1994

Volume

15

Issue

1

Start / End Page

43 / 46

Location

China

Related Subject Headings

  • Spinal Cord
  • Sciatic Nerve
  • Rats, Wistar
  • Rats
  • Proto-Oncogene Proteins c-fos
  • Immunohistochemistry
  • Gene Expression Regulation
  • Formaldehyde
  • Female
  • Capsaicin
 

Citation

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Zhang, M., Ji, R. R., Fang, Y., & Han, J. S. (1994). Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord. Zhongguo Yao Li Xue Bao, 15(1), 43–46.
Zhang, M., R. R. Ji, Y. Fang, and J. S. Han. “Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord.Zhongguo Yao Li Xue Bao 15, no. 1 (January 1994): 43–46.
Zhang M, Ji RR, Fang Y, Han JS. Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord. Zhongguo Yao Li Xue Bao. 1994 Jan;15(1):43–6.
Zhang, M., et al. “Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord.Zhongguo Yao Li Xue Bao, vol. 15, no. 1, Jan. 1994, pp. 43–46.
Zhang M, Ji RR, Fang Y, Han JS. Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord. Zhongguo Yao Li Xue Bao. 1994 Jan;15(1):43–46.

Published In

Zhongguo Yao Li Xue Bao

ISSN

0253-9756

Publication Date

January 1994

Volume

15

Issue

1

Start / End Page

43 / 46

Location

China

Related Subject Headings

  • Spinal Cord
  • Sciatic Nerve
  • Rats, Wistar
  • Rats
  • Proto-Oncogene Proteins c-fos
  • Immunohistochemistry
  • Gene Expression Regulation
  • Formaldehyde
  • Female
  • Capsaicin