L-dopa challenge and relapse in schizophrenia.
Publication
, Journal Article
Davidson, M; Keefe, RS; Mohs, RC; Siever, LJ; Losonczy, MF; Horvath, TB; Davis, KL
Published in: Am J Psychiatry
July 1987
Neuroleptic administration has been shown to be superior to placebo in prolonging schizophrenic remission. However, individual patients are able to maintain long periods of remission in the absence of neuroleptic treatment, while others relapse soon after neuroleptic withdrawal. This study attempted to predict time to relapse in 28 schizophrenic patients withdrawn from neuroleptics and challenged with L-dopa for 7 days, then followed until relapse. Time to relapse correlated significantly with L-dopa-induced increase in BPRS score (p = .006). Five of six patients who responded to L-dopa relapsed within 4 weeks after L-dopa administration, while only four of 22 who did not respond relapsed in a comparable period.
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Published In
Am J Psychiatry
DOI
ISSN
0002-953X
Publication Date
July 1987
Volume
144
Issue
7
Start / End Page
934 / 938
Location
United States
Related Subject Headings
- Schizophrenic Psychology
- Schizophrenia
- Risk
- Recurrence
- Psychiatry
- Psychiatric Status Rating Scales
- Middle Aged
- Male
- Levodopa
- Humans
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MLA
NLM
Davidson, M., Keefe, R. S., Mohs, R. C., Siever, L. J., Losonczy, M. F., Horvath, T. B., & Davis, K. L. (1987). L-dopa challenge and relapse in schizophrenia. Am J Psychiatry, 144(7), 934–938. https://doi.org/10.1176/ajp.144.7.934
Davidson, M., R. S. Keefe, R. C. Mohs, L. J. Siever, M. F. Losonczy, T. B. Horvath, and K. L. Davis. “L-dopa challenge and relapse in schizophrenia.” Am J Psychiatry 144, no. 7 (July 1987): 934–38. https://doi.org/10.1176/ajp.144.7.934.
Davidson M, Keefe RS, Mohs RC, Siever LJ, Losonczy MF, Horvath TB, et al. L-dopa challenge and relapse in schizophrenia. Am J Psychiatry. 1987 Jul;144(7):934–8.
Davidson, M., et al. “L-dopa challenge and relapse in schizophrenia.” Am J Psychiatry, vol. 144, no. 7, July 1987, pp. 934–38. Pubmed, doi:10.1176/ajp.144.7.934.
Davidson M, Keefe RS, Mohs RC, Siever LJ, Losonczy MF, Horvath TB, Davis KL. L-dopa challenge and relapse in schizophrenia. Am J Psychiatry. 1987 Jul;144(7):934–938.
Published In
Am J Psychiatry
DOI
ISSN
0002-953X
Publication Date
July 1987
Volume
144
Issue
7
Start / End Page
934 / 938
Location
United States
Related Subject Headings
- Schizophrenic Psychology
- Schizophrenia
- Risk
- Recurrence
- Psychiatry
- Psychiatric Status Rating Scales
- Middle Aged
- Male
- Levodopa
- Humans