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Lack of B7-2 expression in the germinal centers of aged mice

Publication ,  Journal Article
Miller, C; Kelsoe, G; Han, S
Published in: Aging: Immunology and Infectious Disease
December 1, 1994

The humoral immune response is known to be depressed in the aged mouse. This immunodeficiency is associated with an impairment in the formation of germinal centers, the anatomic site of antibody affinity maturation and memory B cell generation. The formation of germinal centers is dependent on the expression of costimulatory molecules. We have investigated the expression of the recently identified costimulatory molecule, B7-2, and another activation marker, GL7, in the germinal centers of aged mice. In contrast to young syngeneic controls, B7-2 and GL7 are not expressed in the germinal centers of aged C57BL/6 mice. Administration of an antibody specific for the B7-2 molecule produces a defective immune response in young mice that is similar to that seen in old animals. Thus, we propose that the absence of differentiation pathways mediated by B7-2 in aged mice defines a major, age-related immunodeficiency.

Duke Scholars

Published In

Aging: Immunology and Infectious Disease

ISSN

0892-8762

Publication Date

December 1, 1994

Volume

5

Issue

3-4

Start / End Page

249 / 257
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Miller, C., Kelsoe, G., & Han, S. (1994). Lack of B7-2 expression in the germinal centers of aged mice. Aging: Immunology and Infectious Disease, 5(3–4), 249–257.
Miller, C., G. Kelsoe, and S. Han. “Lack of B7-2 expression in the germinal centers of aged mice.” Aging: Immunology and Infectious Disease 5, no. 3–4 (December 1, 1994): 249–57.
Miller C, Kelsoe G, Han S. Lack of B7-2 expression in the germinal centers of aged mice. Aging: Immunology and Infectious Disease. 1994 Dec 1;5(3–4):249–57.
Miller, C., et al. “Lack of B7-2 expression in the germinal centers of aged mice.” Aging: Immunology and Infectious Disease, vol. 5, no. 3–4, Dec. 1994, pp. 249–57.
Miller C, Kelsoe G, Han S. Lack of B7-2 expression in the germinal centers of aged mice. Aging: Immunology and Infectious Disease. 1994 Dec 1;5(3–4):249–257.

Published In

Aging: Immunology and Infectious Disease

ISSN

0892-8762

Publication Date

December 1, 1994

Volume

5

Issue

3-4

Start / End Page

249 / 257