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Kindled seizure-induced reduction of muscarinic cholinergic receptors in rat hippocampal formation: evidence for localization to dentate granule cells.

Publication ,  Journal Article
Savage, DD; Dasheiff, RM; McNamara, JO
Published in: J Comp Neurol
November 20, 1983

The binding of [3H] quinuclidinyl benzilate ( [3H] QNB) to muscarinic cholinergic receptors in dentate gyrus of rat hippocampal formation was analyzed by membrane binding assay and in vitro autoradiography. The destruction of dentate granule cells, either by neonatal irradiation or colchicine injection, resulted in nearly complete elimination of [3H] QNB binding sites in the molecular and granule cell layers. By contrast, neither perforant path transection nor destruction of the septal-hippocampal cholinergic afferents caused a decline of [3H] QNB binding sites. Amygdala kindled seizures resulted in a 30% reduction of [3H] QNB binding sites which was distributed uniformly across the entire molecular and granule cell layers. Thus, most, if not all, of the muscarinic cholinergic receptors present in dentate gyrus appear to reside on the somata and dendritic trees of the dentate granule cells. We propose that this kindled seizure-induced decline of muscarinic receptors represents an endogenous compensatory mechanism designed to stabilize granule cell excitability.

Duke Scholars

Published In

J Comp Neurol

DOI

ISSN

0021-9967

Publication Date

November 20, 1983

Volume

221

Issue

1

Start / End Page

106 / 112

Location

United States

Related Subject Headings

  • Septum Pellucidum
  • Receptors, Muscarinic
  • Rats, Inbred Strains
  • Rats
  • Quinuclidinyl Benzilate
  • Neurology & Neurosurgery
  • Male
  • Kindling, Neurologic
  • Hippocampus
  • Cholinergic Fibers
 

Citation

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Savage, D. D., Dasheiff, R. M., & McNamara, J. O. (1983). Kindled seizure-induced reduction of muscarinic cholinergic receptors in rat hippocampal formation: evidence for localization to dentate granule cells. J Comp Neurol, 221(1), 106–112. https://doi.org/10.1002/cne.902210109
Savage, D. D., R. M. Dasheiff, and J. O. McNamara. “Kindled seizure-induced reduction of muscarinic cholinergic receptors in rat hippocampal formation: evidence for localization to dentate granule cells.J Comp Neurol 221, no. 1 (November 20, 1983): 106–12. https://doi.org/10.1002/cne.902210109.
Savage, D. D., et al. “Kindled seizure-induced reduction of muscarinic cholinergic receptors in rat hippocampal formation: evidence for localization to dentate granule cells.J Comp Neurol, vol. 221, no. 1, Nov. 1983, pp. 106–12. Pubmed, doi:10.1002/cne.902210109.
Journal cover image

Published In

J Comp Neurol

DOI

ISSN

0021-9967

Publication Date

November 20, 1983

Volume

221

Issue

1

Start / End Page

106 / 112

Location

United States

Related Subject Headings

  • Septum Pellucidum
  • Receptors, Muscarinic
  • Rats, Inbred Strains
  • Rats
  • Quinuclidinyl Benzilate
  • Neurology & Neurosurgery
  • Male
  • Kindling, Neurologic
  • Hippocampus
  • Cholinergic Fibers