Kindled seizures selectively reduce a subpopulation of [3H]quinuclidinyl benzilate binding sites in rat dentate gyrus.
Publication
, Journal Article
Savage, DD; McNamara, JO
Published in: J Pharmacol Exp Ther
September 1982
Amygdala-kindled seizures reduced significantly the total number of [3H]quinuclidinyl benzilate binding sites in both dentate and hippocampal gyri compared to electrode implanted unstimulated controls. Both high and low affinity carbachol displaceable binding site populations were significantly reduced in hippocampal gyrus. By contrast, a selective decline of low affinity sites was found in dentate gyrus membranes. The selectivity of the decline in dentate but not hippocampus gyrus underscores the specificity of this molecular response to amygdala-kindled seizures. We suggest that these receptor alterations underlie adaptive mechanisms which antagonize kindled epileptogenesis.
Duke Scholars
Published In
J Pharmacol Exp Ther
ISSN
0022-3565
Publication Date
September 1982
Volume
222
Issue
3
Start / End Page
670 / 673
Location
United States
Related Subject Headings
- Tritium
- Seizures
- Receptors, Muscarinic
- Rats, Inbred Strains
- Rats
- Quinuclidinyl Benzilate
- Quinuclidines
- Pharmacology & Pharmacy
- Male
- Kindling, Neurologic
Citation
APA
Chicago
ICMJE
MLA
NLM
Savage, D. D., & McNamara, J. O. (1982). Kindled seizures selectively reduce a subpopulation of [3H]quinuclidinyl benzilate binding sites in rat dentate gyrus. J Pharmacol Exp Ther, 222(3), 670–673.
Savage, D. D., and J. O. McNamara. “Kindled seizures selectively reduce a subpopulation of [3H]quinuclidinyl benzilate binding sites in rat dentate gyrus.” J Pharmacol Exp Ther 222, no. 3 (September 1982): 670–73.
Savage DD, McNamara JO. Kindled seizures selectively reduce a subpopulation of [3H]quinuclidinyl benzilate binding sites in rat dentate gyrus. J Pharmacol Exp Ther. 1982 Sep;222(3):670–3.
Savage, D. D., and J. O. McNamara. “Kindled seizures selectively reduce a subpopulation of [3H]quinuclidinyl benzilate binding sites in rat dentate gyrus.” J Pharmacol Exp Ther, vol. 222, no. 3, Sept. 1982, pp. 670–73.
Savage DD, McNamara JO. Kindled seizures selectively reduce a subpopulation of [3H]quinuclidinyl benzilate binding sites in rat dentate gyrus. J Pharmacol Exp Ther. 1982 Sep;222(3):670–673.
Published In
J Pharmacol Exp Ther
ISSN
0022-3565
Publication Date
September 1982
Volume
222
Issue
3
Start / End Page
670 / 673
Location
United States
Related Subject Headings
- Tritium
- Seizures
- Receptors, Muscarinic
- Rats, Inbred Strains
- Rats
- Quinuclidinyl Benzilate
- Quinuclidines
- Pharmacology & Pharmacy
- Male
- Kindling, Neurologic