Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.
Publication
, Journal Article
Amara, RR; Villinger, F; Altman, JD; Lydy, SL; O'Neil, SP; Staprans, SI; Montefiori, DC; Xu, Y; Herndon, JG; Wyatt, LS; Candido, MA; Kozyr, NL ...
Published in: Science
April 6, 2001
Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster controlled a highly pathogenic immunodeficiency virus challenge in a rhesus macaque model. Both the DNA and rMVA components of the vaccine expressed multiple immunodeficiency virus proteins. Two DNA inoculations at 0 and 8 weeks and a single rMVA booster at 24 weeks effectively controlled an intrarectal challenge administered 7 months after the booster. These findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the acquired immune deficiency syndrome epidemic.
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
April 6, 2001
Volume
292
Issue
5514
Start / End Page
69 / 74
Location
United States
Related Subject Headings
- Viral Load
- Vaccinia virus
- Vaccines, Synthetic
- Vaccines, DNA
- T-Lymphocytes
- Simian immunodeficiency virus
- Simian Immunodeficiency Virus
- Simian Acquired Immunodeficiency Syndrome
- SAIDS Vaccines
- Macaca mulatta
Citation
APA
Chicago
ICMJE
MLA
NLM
Amara, R. R., Villinger, F., Altman, J. D., Lydy, S. L., O’Neil, S. P., Staprans, S. I., … Robinson, H. L. (2001). Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science, 292(5514), 69–74. https://doi.org/10.1126/science.1058915
Amara, R. R., F. Villinger, J. D. Altman, S. L. Lydy, S. P. O’Neil, S. I. Staprans, D. C. Montefiori, et al. “Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.” Science 292, no. 5514 (April 6, 2001): 69–74. https://doi.org/10.1126/science.1058915.
Amara RR, Villinger F, Altman JD, Lydy SL, O’Neil SP, Staprans SI, et al. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science. 2001 Apr 6;292(5514):69–74.
Amara, R. R., et al. “Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.” Science, vol. 292, no. 5514, Apr. 2001, pp. 69–74. Pubmed, doi:10.1126/science.1058915.
Amara RR, Villinger F, Altman JD, Lydy SL, O’Neil SP, Staprans SI, Montefiori DC, Xu Y, Herndon JG, Wyatt LS, Candido MA, Kozyr NL, Earl PL, Smith JM, Ma HL, Grimm BD, Hulsey ML, Miller J, McClure HM, McNicholl JM, Moss B, Robinson HL. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science. 2001 Apr 6;292(5514):69–74.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
April 6, 2001
Volume
292
Issue
5514
Start / End Page
69 / 74
Location
United States
Related Subject Headings
- Viral Load
- Vaccinia virus
- Vaccines, Synthetic
- Vaccines, DNA
- T-Lymphocytes
- Simian immunodeficiency virus
- Simian Immunodeficiency Virus
- Simian Acquired Immunodeficiency Syndrome
- SAIDS Vaccines
- Macaca mulatta