Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuation.
Publication
, Journal Article
Johnson, RP; Lifson, JD; Czajak, SC; Cole, KS; Manson, KH; Glickman, R; Yang, J; Montefiori, DC; Montelaro, R; Wyand, MS; Desrosiers, RC
Published in: J Virol
June 1999
Three different deletion mutants of simian immunodeficiency virus (SIV) that vary in their levels of attenuation were tested for the ability to protect against mucosal challenge with pathogenic SIV. Four female rhesus monkeys were vaccinated by intravenous inoculation with SIVmac239Delta3, four with SIVmac239Delta3X, and four with SIVmac239Delta4. These three vaccine strains exhibit increasing levels of attenuation: Delta3 < Delta3X
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Published In
J Virol
DOI
ISSN
0022-538X
Publication Date
June 1999
Volume
73
Issue
6
Start / End Page
4952 / 4961
Location
United States
Related Subject Headings
- Virology
- Vagina
- Vaccines, Attenuated
- T-Lymphocytes, Cytotoxic
- SAIDS Vaccines
- Macaca mulatta
- Female
- CD4 Lymphocyte Count
- Antibodies, Viral
- Animals
Citation
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MLA
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Johnson, R. P., Lifson, J. D., Czajak, S. C., Cole, K. S., Manson, K. H., Glickman, R., … Desrosiers, R. C. (1999). Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuation. J Virol, 73(6), 4952–4961. https://doi.org/10.1128/JVI.73.6.4952-4961.1999
Johnson, R. P., J. D. Lifson, S. C. Czajak, K. S. Cole, K. H. Manson, R. Glickman, J. Yang, et al. “Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuation.” J Virol 73, no. 6 (June 1999): 4952–61. https://doi.org/10.1128/JVI.73.6.4952-4961.1999.
Johnson RP, Lifson JD, Czajak SC, Cole KS, Manson KH, Glickman R, et al. Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuation. J Virol. 1999 Jun;73(6):4952–61.
Johnson, R. P., et al. “Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuation.” J Virol, vol. 73, no. 6, June 1999, pp. 4952–61. Pubmed, doi:10.1128/JVI.73.6.4952-4961.1999.
Johnson RP, Lifson JD, Czajak SC, Cole KS, Manson KH, Glickman R, Yang J, Montefiori DC, Montelaro R, Wyand MS, Desrosiers RC. Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuation. J Virol. 1999 Jun;73(6):4952–4961.
Published In
J Virol
DOI
ISSN
0022-538X
Publication Date
June 1999
Volume
73
Issue
6
Start / End Page
4952 / 4961
Location
United States
Related Subject Headings
- Virology
- Vagina
- Vaccines, Attenuated
- T-Lymphocytes, Cytotoxic
- SAIDS Vaccines
- Macaca mulatta
- Female
- CD4 Lymphocyte Count
- Antibodies, Viral
- Animals