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Cryptococcus neoformans: virulence and host defences.

Publication ,  Journal Article
Perfect, JR; Wong, B; Chang, YC; Kwon-Chung, KJ; Williamson, PR
Published in: Med Mycol
1998

Cryptococcus neoformans represents a model organism for the study of virulence and the host response. In this discussion, there is a focus on the genetic, molecular, and biochemical aspects of C. neoformans as it interacts with the host. Investigations into direct and indirect virulence phenotypes are now possible. The molecular aspects of two major virulence factors, capsule and melanin, are characterized. Yeast polyol metabolism through mannitol is examined as a potential biochemical pathway for virulence. The concept of C. neoformans differentially expressed genes within the host or in response to certain environmental cues can be used indirectly to identify potential virulence genes. However, despite significant progress in molecular pathogenesis with C. neoformans, the future of research in this area will require a certain critical mass of investigators to help share in the developmental costs which continue to occur.

Duke Scholars

Published In

Med Mycol

ISSN

1369-3786

Publication Date

1998

Volume

36 Suppl 1

Start / End Page

79 / 86

Location

England

Related Subject Headings

  • Virulence
  • Polysaccharides
  • Microbiology
  • Melanins
  • Humans
  • Genes, Fungal
  • Gene Expression Regulation, Fungal
  • Cryptococcus neoformans
  • Cryptococcosis
  • 3207 Medical microbiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Perfect, J. R., Wong, B., Chang, Y. C., Kwon-Chung, K. J., & Williamson, P. R. (1998). Cryptococcus neoformans: virulence and host defences. Med Mycol, 36 Suppl 1, 79–86.
Perfect, J. R., B. Wong, Y. C. Chang, K. J. Kwon-Chung, and P. R. Williamson. “Cryptococcus neoformans: virulence and host defences.Med Mycol 36 Suppl 1 (1998): 79–86.
Perfect JR, Wong B, Chang YC, Kwon-Chung KJ, Williamson PR. Cryptococcus neoformans: virulence and host defences. Med Mycol. 1998;36 Suppl 1:79–86.
Perfect, J. R., et al. “Cryptococcus neoformans: virulence and host defences.Med Mycol, vol. 36 Suppl 1, 1998, pp. 79–86.
Perfect JR, Wong B, Chang YC, Kwon-Chung KJ, Williamson PR. Cryptococcus neoformans: virulence and host defences. Med Mycol. 1998;36 Suppl 1:79–86.
Journal cover image

Published In

Med Mycol

ISSN

1369-3786

Publication Date

1998

Volume

36 Suppl 1

Start / End Page

79 / 86

Location

England

Related Subject Headings

  • Virulence
  • Polysaccharides
  • Microbiology
  • Melanins
  • Humans
  • Genes, Fungal
  • Gene Expression Regulation, Fungal
  • Cryptococcus neoformans
  • Cryptococcosis
  • 3207 Medical microbiology