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Cryptococcus neoformans: Virulence and host defences

Publication ,  Journal Article
Perfect, JR; Wong, B; Chang, YC; Kwon-Chung, KJ; Williamson, PR
Published in: Journal of Medical and Veterinary Mycology
December 1, 1998

Cryptococcus neoformans represents a model organism for the study of virulence and the host response. In this discussion, there is a focus on the genetic, molecular, and biochemical aspects of C. neoformans as it interacts with the host. Investigations into direct and indirect virulence phenotypes are now possible. The molecular aspects of two major virulence factors, capsule and melanin, are characterized. Yeast polyol metabolism through mannitol is examined as a potential biochemical pathway for virulence. The concept of C. neoformans differentially expressed genes within the host or in response to certain environmental cues can be used indirectly to identify potential virulence genes. However, despite significant progress in molecular pathogenesis with C. neoformans, the future of research in this area will require a certain critical mass of investigators to help share in the developmental costs which continue to occur. © 1998 ISHAM.

Duke Scholars

Published In

Journal of Medical and Veterinary Mycology

ISSN

0268-1218

Publication Date

December 1, 1998

Volume

3

Start / End Page

79 / 86

Related Subject Headings

  • Mycology & Parasitology
 

Citation

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ICMJE
MLA
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Perfect, J. R., Wong, B., Chang, Y. C., Kwon-Chung, K. J., & Williamson, P. R. (1998). Cryptococcus neoformans: Virulence and host defences. Journal of Medical and Veterinary Mycology, 3, 79–86.
Perfect, J. R., B. Wong, Y. C. Chang, K. J. Kwon-Chung, and P. R. Williamson. “Cryptococcus neoformans: Virulence and host defences.” Journal of Medical and Veterinary Mycology 3 (December 1, 1998): 79–86.
Perfect JR, Wong B, Chang YC, Kwon-Chung KJ, Williamson PR. Cryptococcus neoformans: Virulence and host defences. Journal of Medical and Veterinary Mycology. 1998 Dec 1;3:79–86.
Perfect, J. R., et al. “Cryptococcus neoformans: Virulence and host defences.” Journal of Medical and Veterinary Mycology, vol. 3, Dec. 1998, pp. 79–86.
Perfect JR, Wong B, Chang YC, Kwon-Chung KJ, Williamson PR. Cryptococcus neoformans: Virulence and host defences. Journal of Medical and Veterinary Mycology. 1998 Dec 1;3:79–86.

Published In

Journal of Medical and Veterinary Mycology

ISSN

0268-1218

Publication Date

December 1, 1998

Volume

3

Start / End Page

79 / 86

Related Subject Headings

  • Mycology & Parasitology