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Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells.

Publication ,  Journal Article
Perfect, JR; Granger, DL; Durack, DT
Published in: J Infect Dis
August 1987

The activated macrophage may play a central role in host effector mechanisms against invading fungi. Here we demonstrate the importance of the activation state of murine macrophages for both fungistatic and fungicidal activity. Host factors such as gamma interferon and microbial products such as endotoxin can interact synergistically to initiate this cytotoxicity. This activated state may be aided by antifungal agents such as amphotericin B. Both a methyl ester derivative of amphotericin B and liposomal amphotericin B Both a methyl ester derivative of amphotericin B and liposomal amphotericin B potentiated macrophage activation but were less potent than amphotericin B. Other available antifungal agents such as azole compounds and flucytosine did not possess this ability to interact with the intrinsic macrophage effector mechanisms. However, ketoconazole and itraconazole avidly bind to macrophages as the biologically active drug. The azole-loading of macrophages may be a factor in macrophage cytotoxicity for fungi.

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Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

August 1987

Volume

156

Issue

2

Start / End Page

316 / 323

Location

United States

Related Subject Headings

  • Neoplasms, Experimental
  • Microbiology
  • Mice
  • Macrophages
  • Macrophage Activation
  • Liposomes
  • Interferon-gamma
  • Fungi
  • Endotoxins
  • Cytotoxicity, Immunologic
 

Citation

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Perfect, J. R., Granger, D. L., & Durack, D. T. (1987). Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells. J Infect Dis, 156(2), 316–323. https://doi.org/10.1093/infdis/156.2.316
Perfect, J. R., D. L. Granger, and D. T. Durack. “Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells.J Infect Dis 156, no. 2 (August 1987): 316–23. https://doi.org/10.1093/infdis/156.2.316.
Perfect JR, Granger DL, Durack DT. Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells. J Infect Dis. 1987 Aug;156(2):316–23.
Perfect, J. R., et al. “Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells.J Infect Dis, vol. 156, no. 2, Aug. 1987, pp. 316–23. Pubmed, doi:10.1093/infdis/156.2.316.
Perfect JR, Granger DL, Durack DT. Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells. J Infect Dis. 1987 Aug;156(2):316–323.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

August 1987

Volume

156

Issue

2

Start / End Page

316 / 323

Location

United States

Related Subject Headings

  • Neoplasms, Experimental
  • Microbiology
  • Mice
  • Macrophages
  • Macrophage Activation
  • Liposomes
  • Interferon-gamma
  • Fungi
  • Endotoxins
  • Cytotoxicity, Immunologic